A randomized study of continuing versus holding metformin during hospitalizations to internal medicine services to determine the effects on glucose control, acidosis, abdominal symptoms, length of stay, and mortality.
The purpose of this study is to determine what the effects of the routine practice of holding metformin in hospitalized patients with type 2 diabetes are on outcomes. The objectives of this study are to determine how holding versus continuing metformin during hospitalization to an internal medicine service affects the incidences of lactic acidosis, mean anion gap, mean glucose levels, low and very high blood sugars, GI effects after discharge, lack of continuation of metformin upon discharge, mean glucose levels, lengths of stay, and 30-day mortality.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
22
Continuation of home metformin
University of Illinois at Chicago
Chicago, Illinois, United States
Mean glucose levels
Average of daily glucose levels during hospitalization
Time frame: During hospitalization
Incidence of hyperglycemia greater than 300 mg/dl.
Glucose \> 300
Time frame: During hospitalization
Incidence of hypoglycemia (Glu = 54 - 70).
Glu = 54 - 70
Time frame: During hospitalization
Incidence of moderate hypoglycemia (Glu < 54)
Glu \< 54
Time frame: During hospitalization
Incidence of severe hypoglycemia (Glu < 54 with symptoms)
Glu \< 54 with symptoms
Time frame: During hospitalization
Mean lactic acid levels.
Mean lactic acid levels
Time frame: During hospitalization
Incidence of lactic acid levels greater than 2.0.
Lactic acid \> 2.0
Time frame: During hospitalization
Mean anion gap.
Mean anion gap, a calculated value
Time frame: During hospitalization
Incidence of anion gap > 11
Anion Gap \> 11
Time frame: During hospitalization
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Incidence of elevated lactic acid level or anion gap.
Lactic acid \> 2.0 or Anion Gap \> 11
Time frame: During hospitalization
Incidence of inadvertently not continuing metformin on discharge
Transitions of care
Time frame: At discharge
GI adverse effects
GI side effects after discharge
Time frame: Within 3 days of discharge
Mortality
Mortality as determined via chart search and follow up phone call
Time frame: 30 +/- 3 days after discharge