The purpose of this study is to compare how effective and how tolerable two different bowel preparation laxatives are for colonoscopy. The aim is to compare oral sulfate solution (OSS) to another laxative called 2L polyethylene glycol (PEG) solution to see which is more effective and more tolerable by individuals with IBD (Crohn's disease or Ulcerative colitis).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
418
Laxative for colonoscopy bowel preparation
Laxative for colonoscopy bowel preparation
University of Manitoba
Winnipeg, Manitoba, Canada
RECRUITINGQuality of bowel cleanliness
The primary outcome will be adequate quality of bowel cleanliness. Proportion with adequate cleansing will be measured by Boston Bowel Preparation Scale Score ≥2 in all segments.
Time frame: 1 year
Quality of bowel cleanliness
The primary outcome will be adequate quality of bowel cleanliness. Proportion with adequate cleansing will be measured by the Ottawa scale score as a binary adequate/inadequate score (≤7) will be recorded.
Time frame: 1 year
Volume of laxative intake
Will compare completion of laxative intake.
Time frame: 1 year
Endoscopic Outcomes
Will compare dysplasia detection rate.
Time frame: 1 year
Endoscopic Outcomes
Will compare withdrawal time.
Time frame: 1 year
Endoscopic Outcomes
Will compare total procedure time.
Time frame: 1 year
Endoscopic Outcomes
Will compare cecal intubation rate
Time frame: 1 year
Patient experience data
Will determine the proportion of patients in each group reporting: use of split dose and day before bowel preparation (even though they were prescribed split-dose) , incontinence episodes during bowel preparation and during travel to the colonoscopy appointment; total duration of sleep; number of nocturnal awakenings: patient willingness to repeat colonoscopy using the same preparation; pre-colonoscopy anxiety rating; difficulty with bowel preparation rating. The study specific patient questionnaire will be administered prior to the colonoscopy to avoid any contamination by the experience of the colonoscopy.
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Time frame: 1 year
Crohn's disease or ulcerative colitis flares after colonoscopy
A one month phone call to determine diagnosed flares within a month
Time frame: One month
Endoscopic Outcomes
Will also compare the proportion of patients requiring repeat colonoscopy because of an inadequate bowel preparation. Will collect data on mucosal abnormality suspected by endoscopist to be due to bowel preparation.
Time frame: 1 year