Systemic Inflammatory Indices as a Non-invasive Grading Modality for Endometriosis

Benha University88 enrolled

Overview

Endometriosis (EMs) is one of the commonest chronic inflammatory disorder affecting women and is characterized by the presence and growth of endometrial-like glandular epithelial and stromal cells outside the uterus leading to multiple clinical symptoms affecting patients quality of life and fertility with high recurrence rate . The systemic immune inflammatory index (SII) and systemic inflammatory response index (SIRI) are documented as prognostic serum biomarker in many kinds of cancer and for the need and outcomes of adjuvant therapies for various cancers .

Study Type

OBSERVATIONAL

Enrollment

Conditions

Endometriosis

Interventions

Diagnostic laparoscopyPROCEDURE

All women will undergo exploratory laparoscopy under general anesthesia

Full Blood Count (FBC)DIAGNOSTIC_TEST

Blood samples withdrawn from patients on EDITA tubes and gone through full blood count and differential leucocytic count

Eligibility

Sex: FEMALEMin age: 25 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women with clinical manifestations suggestive of having EM; * Women who was professionally diagnosed; * Women who was diagnosed by radiologic workup; * Women were free of exclusion criteria. Exclusion Criteria: * Women with EM and were maintained on treatment or underwent operative interference during the last three months; * Patients had autoimmune diseases, maintained on immunosuppressive therapy for any indication; * Women with cancer elsewhere in the body or receiving adjuvant therapies for cancer; * Patients receiving therapies for viral disorders especially COVID; * Patients refusing to undergo the exploratory laparoscopy.

Locations (1)

Benha University

Banhā, Al Qalyobia, Egypt

Outcomes

Primary Outcomes

Indices' ability to predict EM stage

Number of patients was diagnosed with EM and got staged right through a calculated indices to the patients who went for exploratory laparoscopy which improve the chances of calculated indices facing the laparoscopy.

Time frame: 8 months

Data from ClinicalTrials.gov

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