The prefrontal cortex, although well established as an efficacious target for the treatment of major depressive disorder (MDD), has recently come into favour as a therapeutic target for alcohol use disorders (AUD). Depressive symptoms are also highly prevalent in individuals with AUD. A number of cognitive and psychological processes stemming from the prefrontal cortex, a common treatment target for repetitive transcranial magnetic stimulation (rTMS), are disrupted in both MDD and AUD. The proposed study will enhance the development of theta burst stimulation (TBS) as a new intervention for AUD in the context of depressive symptoms and uses integrated TMS-EEG to identify neurophysiological targets of executive dysfunction in this disorder.
The prefrontal cortex, although well established as an efficacious target for the treatment of major depressive disorder (MDD), has recently come into favour as a therapeutic target for alcohol use disorders (AUD). Depressive symptoms are also highly prevalent in individuals with AUD. A number of cognitive and psychological processes stemming from the prefrontal cortex, a common treatment target for repetitive transcranial magnetic stimulation (rTMS), are disrupted in both MDD and AUD. The proposed study will enhance the development of theta burst stimulation (TBS) as a new intervention for AUD in the context of depressive symptoms and uses integrated TMS-EEG to identify neurophysiological targets of executive dysfunction in this disorder.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
40
Theta-burst stimulation
Stimulation with double-sided B70-type coil
Centre for Addiction and Mental Health
Toronto, Ontario, Canada
RECRUITINGExecutive Function Index - inhibition
Flanker task
Time frame: baseline and 4 weeks after baseline (after 20 treatments of active/sham rTMS)
Executive Function Index - working memory
N-back task
Time frame: baseline and 4 weeks after baseline (after 20 treatments of active/sham rTMS)
Executive Function Index - set shifting
switch task
Time frame: baseline and 4 weeks after baseline (after 20 treatments of active/sham rTMS)
17-Item Hamilton Depression Rating Scale (HRSD-17)
Decrease in 17-Item Hamilton Depression Rating Scale score, 0 is lowest value, 52 is highest, higher value = more severe depression
Time frame: baseline and 4 weeks after baseline (after 20 treatments of active/sham rTMS)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.