To compare efficacy of cetylated fatty acid with placebo for reducing postoperative pain after unilateral TKA. The hypothesis is topical cetylated fatty acid can mitigate postoperative pain after TKA.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
80
use approximately 3 cm long of cream per each side of knee, then apply on the operated knee until completely absorb
use approximately 3 cm long of cream per each side of knee, then apply on the operated knee until completely absorb
department of orthopaedic surgery, Faculty of medicine, Thammasat university
Khlong Luang, Changwat Pathum Thani, Thailand
RECRUITINGVisual analog scale
VAS (0-100) at rest and on motion
Time frame: post-op Day2
Visual analog scale
VAS (0-100) at rest and on motion
Time frame: post-op week2
Visual analog scale
VAS (0-100) at rest and on motion
Time frame: post-op week6
Visual analog scale
VAS (0-100) at rest and on motion
Time frame: post-op week12
inflammatory marker
ESR and CRP
Time frame: post-op day2
inflammatory marker
ESR and CRP
Time frame: post-op week2
inflammatory marker
ESR and CRP
Time frame: post-op week6
inflammatory marker
ESR and CRP
Time frame: post-op week12
Knee skin temperature
evaluated by digital infrared thermometer at 4 different locations on the anterior aspect of the knee independently (superomedial, superolateral, inferomedial, inferolateral borders of the patella) compared with the contralateral knee
Time frame: post-op Day2
Knee skin temperature
evaluated by digital infrared thermometer at 4 different locations on the anterior aspect of the knee independently (superomedial, superolateral, inferomedial, inferolateral borders of the patella) compared with the contralateral knee
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Time frame: post-op week2
Knee skin temperature
evaluated by digital infrared thermometer at 4 different locations on the anterior aspect of the knee independently (superomedial, superolateral, inferomedial, inferolateral borders of the patella) compared with the contralateral knee
Time frame: post-op week6
Knee skin temperature
evaluated by digital infrared thermometer at 4 different locations on the anterior aspect of the knee independently (superomedial, superolateral, inferomedial, inferolateral borders of the patella) compared with the contralateral knee
Time frame: post-op week12
Knee circumference (cm)
Measured by tape at midpoint of patella
Time frame: post-op Day2
Knee circumference (cm)
Measured by tape at midpoint of patella
Time frame: post-op week2
Knee circumference (cm)
Measured by tape at midpoint of patella
Time frame: post-op week6
Knee circumference (cm)
Measured by tape at midpoint of patella
Time frame: post-op week12
Knee Range of Motion
Flexion and extension angle
Time frame: post-op Day2
Knee Range of Motion
Flexion and extension angle
Time frame: post-op week2
Knee Range of Motion
Flexion and extension angle
Time frame: post-op week6
Knee Range of Motion
Flexion and extension angle
Time frame: post-op week12
Modified WOMAC
Total \& Subscore
Time frame: post-op week2
Modified WOMAC
Total \& Subscore
Time frame: post-op week6
Modified WOMAC
Total \& Subscore
Time frame: post-op week12
Thai forgotten joint score
Time frame: post-op week2
Thai forgotten joint score
Time frame: post-op week6
Thai forgotten joint score
Time frame: post-op week12