Effect of Vitamin D Injection on Hypertrophic Scars and Keloids

Mostafa Bahaa35 enrolled

Overview

Scars and keloids cause patients severe morbidity and psychological distress. Hypertrophic scars rise above the skin but stay within the scar boundaries, while keloids expand. The development of keloids and hypertrophic scars is a consequence of insufficient wound healing. These lesions are distinguished by excessive ECM deposition. Excessive ECM deposition is caused by increased inflammatory and proliferative processes and decreased remodeling activities. These scarring lesions are also linked to genetic and systemic causes

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Dermatologic Disease

Interventions

CholecalciferolDRUG

Vitamin D has various critical regulatory roles, including inflammatory control, cellular proliferation and differentiation, and wound healing regulation.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: \- Age from 12 years to 50 years. Patients with hypertrophic scars and keloids Exclusion Criteria: Age below 12 years and above 50 years. Patients received other treatment modalities for hypertrophic scars and keloids. Systemic and other skin diseases. Patients were already receiving supplemental vitamin D.

Locations (1)

faculty of medicine-Fayoum university

Al Fayyum, Egypt

Outcomes

Primary Outcomes

Clinical scoring by Vancouver Scale Score

Four characteristics of the scar are assessed. These are: vascularity, height, pliability, and pigmentation. Each characteristic is given a score, which are added together to give an overall score between 0 and 13

Time frame: 3 months

Data from ClinicalTrials.gov

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