The goal of this observational study is to learn about long term symptoms in oesophageal cancer survivors. The main question it aims to answer is are: * Study the changes in gut bacteria by examining saliva, stool and blood. * Investigate the products of bacteria in breath to develop a non-invasive breath test to detect the changes in gut bacteria. * Develop new strategies to treat this change and trial new treatments to improve quality- of-life in oesophageal cancer survivors. Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of breath, saliva, blood, urine, stool and complete validated healthy-related quality-of-life questionnaires. Researchers will compare symptomatic and asymptomatic participants to detect the changes stated above.
Study Type
OBSERVATIONAL
Enrollment
100
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of breath.
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of saliva.
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of blood.
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of urine.
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of stool.
Participants will attend an outpatient clinic and complete validated healthy-related quality-of-life questionnaires.
Barking, Havering and Redbridge University Hospitals NHS Trust
London, United Kingdom
Imperial College Healthcare NHS Trust
London, United Kingdom
West Hertfordshire NHS Teaching Hospitals
London, United Kingdom
Identify microbiome dysbiosis in saliva associated with long-term functional symptoms.
Metagenomic sequencing of saliva samples.
Time frame: 24 months
Identify microbiome dysbiosis in stool associated with long-term functional symptoms.
Metagenomic sequencing of stool samples.
Time frame: 24 months
Identify underlying metabolic pathways associated with microbiome derived metabolites.
Bioinformatic multi-omic pathway analysis.
Time frame: 36 months
Develop a breath test to detect volatile biomarkers associated with microbiome dysbiosis.
Gas Chromatography-Mass Spectrometry (GC-MS) will be used to identify the levels (measured in parts per billion, ppb) of certain microbiome-derived VOCs in breath.
Time frame: 36 months
Propose a strategy for treatment of long-term symptoms in oesophageal adenocarcinoma survivors.
Identify therapeutic targets and interventions to manipulate dysbiotic microbiota
Time frame: 36 months
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