Inorganic nitrite and nitrate can be reduced to NO and NO-related species such as S-nitrosothiols via the nitrate-nitrite-NO pathway. This is due to the reduction of nitrate to nitrite by the action of bacteria in the mouth and the reduction of nitrite to NO depending on the acidic pH on the stomach or by enzymes with nitrite-reductase activity. The acidic environment of the stomach is very important to the formation of NO and S-nitrosothiols and several studies suggest that changes in gastric pH can affect this conversion. In this context, bariatric surgery, by altering the anatomy of the stomach and increasing gastric pH, can affect the nitrate-nitrite-NO pathway and change the antihypertensive and antioxidant effect of sodium nitrate.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
30
Sodium Nitrate
Usp - Hospital Das Clínicas Da Faculdade de Medicina de Ribeirão
Ribeirão Preto, São Paulo, Brazil
Assess changes in s-nitrosothiols
Change in s-nitrosothiols concentration in plasma After Sodium Nitrate Treatment
Time frame: 14 days
Assess changes in blood pressure
Change in Blood Pressure After Sodium Nitrate Treatment by Ambulatory blood pressure monitors (ABPMs)
Time frame: 14 days
Assess changes in endotelial function
Change in endotelial function After Sodium Nitrate Treatment by Endopat
Time frame: 14 days
Assess changes in Vascular stiffness
Change in Vascular stiffness After Sodium Nitrate Treatment by pulse wave velocity (PWV)
Time frame: 14 days
Assess changes in nitrate concentration
Change in nitrate concentration in plasma After Sodium Nitrate Treatment
Time frame: 14 days
Assess changes in nitrite concentration
Change in nitrite concentration in plasma After Sodium Nitrate Treatment
Time frame: 14 days
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