NLR and PLR Levels Following IPACK Block in Knee Arthroplasty

Poznan University of Medical Sciences60 enrolled

Overview

Effect of iPACK block on NLR and PLR following knee arthroplasty

The NLR is a sensitive indicator of inflammation confirmed in numerous studies and has a predictive and prognostic value. NLR is a cheap, simple, fast-acting, readily available stress and inflammation parameter with high sensitivity and low specificity. Dynamic changes in the NLR precede the clinical state for several hours and may alert clinicians early about the ongoing pathological process. NLR is a new promising marker of cellular immune activation, an important indicator of stress and systemic inflammation. It opens a new dimension for clinical medicine to understand better the biology of inflammation, the linkage, and antagonism between innate and adaptive immunity, and its clinical consequences for health and disease. NLR is affected not only by surgical trauma but also by the method of anesthesia. In recent years, the influence of regional anesthesiology on reducing the inflammatory response after surgical procedures has been emphasized. However, there have been very few studies evaluating the effect of various methods of anesthesia on the NLR. This is the first study to investigate the effect of regional anesthesia on the NLR and PLR in patients undergoing knee replacement surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Knee Arthropathy Knee Osteoarthritis Knee Pain Chronic

Interventions

0.9% Sodium Chloride InjectionDRUG

After spinal anesthesia, the ultrasound-guided iPACK block will be performed with 20ml of 0.9% sodium chloride

Ropivacaine 0.2% Injectable SolutionDRUG

After spinal anesthesia, the ultrasound-guided iPACK block will be performed with 20ml of 0.2% ropivacine

Eligibility

Sex: ALLMin age: 20 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with ASA classification I-III * Aged 20-90 years * Who will be scheduled for hip arthroplasty under spinal anesthesia Exclusion Criteria: * Patients who have a history of bleeding diathesis * Take anticoagulant therapy * History of chronic pain before surgery * Multiple trauma * patients unable to assess their pain (dementia) * patients operated under general anesthesia * patients having an infection in region of the procedure * patient who do not accept the procedure

Locations (1)

Poznan University of Medical Sciences

Poznan, Poznań, Poland

Outcomes

Primary Outcomes

Neutrophil-to-lymphocyte ratio

Neutrophil to lymphocyte ratio (NLR) is used as a marker of subclinical inflammation. It is calculated by dividing the number of neutrophils by number of lymphocytes, usually from peripheral blood sample, but sometimes also from cells that infiltrate tissue, such as tumor.

Time frame: 12 hours after surgery

Secondary Outcomes

PLR

Platelet-to-lymphocyte ratio

Time frame: 12 hours after surgery

PLR

Platelet-to-lymphocyte ratio

Time frame: 24 hours after surgery

PLR

Platelet-to-lymphocyte ratio

Time frame: 48 hours after surgery

NLR

Neutrophile-to-lymphocyte ratio

Time frame: 24 hours after surgery

NLR

Neutrophile-to-lymphocyte ratio

Time frame: 48 hours after surgery

first need of opiate

Time after surgery when the patient needs opiate for the first time

Time frame: 48 hours after procedure

Opioid Consumption

Total opiate consumption after surgery

Time frame: 48 hours after surgery

Pain score

NRS (Numerical Rating Scale)

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.