Protocol Optimization in CT for the Quantification of BMD

Hatem Alkadhi167 enrolled

Overview

Bone mineral density is an important measurement to detect osteoporosis. The goal of this clinical trial is to compare bone mineral density measurements in CT examinations and DXA scans. The main question it aims to answer is: * How good is the measurement of bone mineral density in the new photon-counting CT in comparison to DXA * How can we optimize the CT scan for bone mineral density Participants will undergo: * Clinically indicated CT scan on day of inclusion * Study related DXA scan on a separate appointment

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

167

Conditions

Osteoporosis, Osteopenia Bone Loss

Interventions

Bone Mineral Density quantificationDIAGNOSTIC_TEST

In the first visit, participants receive clinically indicated CT scan, where bone mineral density will be derived. In a second, study related visit, participants will receive a DXA scan for bone mineral quantifications.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Informed Consent signed by the subject * Referral to a regular clinically indicated CT examination covering the lumbar area (e.g., Abdomen, Thorax + Abdomen, Neck + Thorax +Abdomen) * Informed written and oral consent (interpreter present in case of foreign language patients) * No contraindication to the clinically indicated CT examination Exclusion Criteria: * Patients \< 18 years * Pregnant women * Vulnerable subjects * Contraindications to the clinically indicated CT scan * Multiple Myeloma * Diffuse bone metastasis * Fixateur interne in the lumbar spine * Kyphoplasty in the lumbar spine * Enterally administrated contrast agent * Obtaining informed consent is not possible * Withdrawal of consent orally or in writing * Inability to follow the procedures of the investigation, e.g., due to language problems, psychological disorders, dementia, etc. of the subject * Immobility (patients confined to a wheelchair or to bed)

Locations (1)

Diagnostic and Interventional Radiology, University Hospital Zurich

Zurich, Canton of Zurich, Switzerland

Outcomes

Primary Outcomes

Bone mineral density CT

Bone mineral density derived from CT Scan

Time frame: Immediately after CT scan of the participant.

Bone mineral density Dual-energy x-ray absorptiometry (DXA)

Bone mineral density derived from DXA Scan

Time frame: Immediately after DXA scan of the participant.

Secondary Outcomes

Correlation between age and bone mineral density

Correlation analysis by means of linear regression and pearson correlation between age (in years) and bone mineral density

Time frame: 1 year

Correlation between sex and bone mineral density

Correlation analysis by means of linear regression and pearson correlation between sex (male/female) and bone mineral density

Time frame: 1 year

Correlation between height and bone mineral density

Correlation analysis by means of linear regression and pearson correlation between height (in cm) and bone mineral density

Time frame: 1 year

Correlation between weight and bone mineral density

Correlation analysis by means of linear regression and pearson correlation between weight and bone mineral density

Time frame: 1 year

Correlation between body mass index (BMI) and bone mineral density

Correlation analysis by means of linear regression and pearson correlation between body mass index (BMI, in kg/m\^2) and bone mineral density

Time frame: 1 year

Data from ClinicalTrials.gov

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