The aim of this study was to investigate the accuracy of quantitative flow ratio (QFR) for predicting fractional flow reserve (FFR) ≤0.80 in an independent core laboratory.
FFR is an invasive physiological index used to define coronary stenosis that causes ischemia. Several studies have suggested that FFR-based percutaneous coronary intervention (PCI) can reduce adverse clinical outcomes compared to angiography-guided PCI. Although FFR is highly recommended in current guidelines, it is underused in real-world practice. QFR is a method for evaluating fractional flow reserve FFR without the use of an invasive coronary pressure wire or pharmacological hyperemic agent. The aims of this study were: 1. To investigate diagnostic accuracy of angiography-based QFR for hemodynamic assessment of coronary artery stenosis compared to pressure wire-based FFR. 2. To compare the diagnostic performance of QFR versus % diameter stenosis (DS) in identifying physiologically significant coronary artery disease (CAD) using FFR as the reference standard. 3. To identify factors affecting QFR accuracy. 4. To compare the coronary CT data with QFR.
Study Type
OBSERVATIONAL
Enrollment
280
Patients suspected with CAD undergoing diagnostic coronary angiography with an indication for to perform invasive FFR were included. QFR was analyzed in an independent core laboratory (Uijeongbu Eulji Medical Center) using the software package QAngio XA 3D 2.1 (Medis Medical Imaging Systems, Leiden, the Netherlands).
Seoul National University Hospital
Seoul, South Korea
Diagnostic accuracy of QFR
Diagnostic accuracy of QFR (≤0.80 or \>0.80) to determine hemodynamically significant coronary stenosis using invasive FFR (≤0.80 or \>0.80) as a reference standard
Time frame: through study completion, an average of 1 year
Sensitivity of QFR
Sensitivity of contrast QFR to predict FFR lower than 0.8
Time frame: through study completion, an average of 1 year
Specificity of QFR
Specificity of contrast QFR to predict FFR lower than 0.8
Time frame: through study completion, an average of 1 year
Correlation
Correlation between QFR and FFR
Time frame: through study completion, an average of 1 year
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