A Study to Assess the Efficacy and Safety of Burfiralimab (hzVSF-v13) and DMRD (Disease-modifying Antirheumatic Drug)

Inclusion Criteria: 1. Participant has a diagnosis of adult-onset RA for at least 3 months prior to Screening, as defined by the 2010 ACR/European League Against Rheumatism (EULAR) classification criteria. 2. Participant has moderate to severe RA at Screening and Baseline. 3. Participant has had an inadequate response to, loss of response, or intolerance to at least 2 bDMARDs or tsDMARDs. 4. Participant is positive for anti-citrullinated protein antibodies (ACPA). 5. Participant has a C-reactive protein (CRP) \> upper limit normal (ULN) (5.0 g/L). 6. Participant has a negative tuberculosis test at Screening, defined as either negative QuantiFERON® test or purified protein derivative \<5 mm of induration at 48 to 72 hours after the test was placed. Exclusion Criteria: 1. Participant has Class IV RA according to ACR revised response criteria. 2. Participant has 1 or more significant concurrent medical conditions per investigator judgment, including but not limited to the following: * Poorly controlled diabetes or hypertension, * Chronic kidney disease stage IIIb, IV, or V, * Symptomatic heart failure according to New York Heart Association Classes II, III, or IV, * Myocardial infarction, unstable angina pectoris, stroke, or transient ischemic attack, within the past 12 months before randomization, * Severe chronic pulmonary disease, for example, requiring oxygen therapy, * Clinically significant hepatic diseases (i.e., hemochromatosis, Wilson's disease, alcoholic hepatitis, autoimmune liver disease, nonalcoholic steatohepatitis, or α-1-antitrypsin deficiency, 3. Participant has known history of prosthetic or native joint infection or human immunodeficiency virus or neurologic symptoms suggestive of central nervous system demyelinating disease. 4. Participant has a chronic inflammatory disease or connective tissue disease other than RA, including but not limited to; systemic lupus erythematosus, psoriatic arthritis, axial spondyloarthritis including ankylosing spondylitis and non radiographic axial spondylarthritis, reactive arthritis, gout, scleroderma, polymyositis, dermatomyositis and/or active fibromyalgia and/or multiple sclerosis.