Research background and project basis Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder characterized by social disorders and repetitive stereotypical behavior. Social memory impairment is a significant feature of ASD patients, and the specific pathogenesis of social memory impairment in ASD patients is currently unclear, and there are no objective indicators to measure social memory levels. Sleep spindle wave is a special brain wave in sleep that is closely related to memory consolidation. However, no one has yet studied the impact of sleep spindles on social memory. Research purpose Exploring the correlation between sleep spindles and social memory in the population, providing reference for the auxiliary diagnosis of social memory disorders in children with ASD.
The goal of this observational study is to exploring the correlation between sleep spindles and social memory in the population, providing reference for the auxiliary diagnosis of social memory disorders in children with autism spectrum disorders(ASD). The main question it aims to answer is the effect of sleep spindles on social memory. The study clinically recruited 30 children with ASD and 30 normal children. Participants will be asked to take face and car recognition memory tests which car recognition memory test as a control. After the two tasks, nighttime EEG recordings and subsequent spindle analysis will be recorded and performed.Then the correlation analysis between social memory levels and spindle levels would be conducted by machine learning model, so that researchers can infer the individual's social memory level through the level of spindles in the EEG.
Study Type
OBSERVATIONAL
Enrollment
60
Take a face recognition memory test, and a car recognition memory test as a control . Then record nighttime EEG recordings after the two tasks and performed subsequent spindle analysis.So conduct the correlation between social memory levels and the level of spindles in the EEG by using machine learning to model.
First Afflicated Hospital Xian Jiaotong University
Xi'an, Shaanxi, China
RECRUITINGRecognition accuracy
Recognition accuracy as an evaluation indicator for cars and facial recognition. The car and face recognition task included a learning phase on the first night (approximately 30 minutes before going to bed) and a recognition test phase on the second morning (approximately 30 minutes after waking up). The learning phase included 11 pictures of adult faces (319 × 432 pixel). During the learning phase, pictures were randomly presented for 3s with an inter-stimulus interval of 2s. During the test phase, two pictures were presented simultaneously, with the picture from the study list (called "old") paired with an unseen picture (called "new"), in random left-right order. Participants were asked to select a picture they had seen previously by pressing the left and right buttons. And the next stimulus was presented immediately after the participant answered. Recognition accuracy was computed as the number of correct responses (hits).
Time frame: Through face & car recognition task completion, an average of 2-4 days.
Response delay time
Reaction time is commonly used to evaluate cognitive abilities. Mean reaction times (ms) were calculated for correct responses (hits), which is the response delay time.
Time frame: Through face & car recognition task completion, an average of 2-4 days.
Sleep spindle density
Sleep spindle wave recognition and data processing use the YASA (Yet Another Spindle Algorithm) toolbox based on Python to stage EEG sleep automatic recognition of sleep spindle waves. Calculate the density (N/min) of sleep spindles.
Time frame: Through the 12 hour EEG recording completion, an average of 5-12 days.
Sleep spindle average duration
Calculate the average duration (s) of single spindle.
Time frame: Through the 12 hour EEG recording completion, an average of 5-12 days.
Sleep spindle amplitude
Amplitude (μV) refers to the maximum energy value possessed by the spindle wave.
Time frame: Through the 12 hour EEG recording completion, an average of 5-12 days.
Sleep spindle frequency
Frequency (Hz) refers to the number of times the spindle wave vibrates repeatedly per second.
Time frame: Through the 12 hour EEG recording completion, an average of 5-12 days.
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