Influence of Intraoperative Blood Salvage and Autotransfusion on Tumor Recurrence After Deceased Donor Liver Transplantation

Zhejiang University998 enrolled

Overview

The practice of intraoperative blood salvage and autotransfusion (IBSA) during deceased donor liver transplantation (DDLT) for hepatocellular carcinoma (HCC) can potentially reduce the need for allogeneic blood transfusion. However, implementing IBSA remains debatable due to concerns about its possible detrimental effects on oncologic recurrence. Hence, a nationwide multi-center study was conducted to investigate further the association between IBSA and post-transplant HCC recurrence, including a stratified subgroup analysis.

Study Type

OBSERVATIONAL

Enrollment

998

Conditions

Liver Transplant; Complications

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adult-to-adult deceased donor liver transplantation for hepatocellular carcinoma Exclusion Criteria: * patients under 18 years of age * presence of extrahepatic metastasis * combined kidney transplantation * reduced-size or split liver transplantation * re-transplantation

Outcomes

Primary Outcomes

Postoperative recurrence of liver cancer

The overall incidence of HCC recurrence (intrahepatic or extrahepatic) after LT.

Time frame: 2015.1.1-2020.12.31