Seminal Levels of PGK2 and ACRV1 as Predictors of Micro-TESE Results in NOA

N/ANot Yet RecruitingNCT06307639

Assiut University64 enrolled

Overview

* Measurement of PGK2 and ACRV1 levels in the semen of infertile males undergoing testicular sperm extraction (TESE). * Correlate seminal levels of PGK2 and ACRV1 with sperm retrieval results and histopathology analysis of testicular biopsy samples.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Male Infertility Due to Azoospermia

Interventions

Measurement of PGK2 and ACRV1 levels in the semen of infertile males undergoing testicular sperm extraction (TESE).DIAGNOSTIC_TEST

Measurement of PGK2 and ACRV1 levels in the semen of infertile males undergoing testicular sperm extraction (TESE).

Eligibility

Sex: MALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Infertile males with normal volume, functional (non-obstructive) azoospermia. * Age: 18-45 years Exclusion Criteria: * Patients with proven obstructive azoospermia. * Cryptorchidism. * Testicular Agenesis and testicular atrophy. * Patient with exposure to gonadal toxins like chemotherapy, radiotherapy, and alkylating agents.

Outcomes

Primary Outcomes

Know more about the functional role of PGK2 and ACRV1 in the process of spermatogenesis.

Time frame: 2 years

Detect if PGK2 and/or AVRV1 level can used as predictor for spermatogenesis in infertile men with non-obstructive azoospermia undergoing Testicular Sperm Extraction.

Time frame: 2 years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.