To explore the role of CGF in the regeneration or preservation of soft and hard tissues during tooth extraction site preservation surgery.
A prospective, randomized controlled trial is designed to explore the role of CGF in the regeneration or preservation of soft and hard tissues in extraction site preservation. Using random number table, 20 patients were randomly divided into 4 groups using different filling materials in the extraction socket and materials for the wound sealing. Group A (5cases): bone powder + collagen membrane; Group B (5 cases): bone powder + collagen membrane + CGF membrane; Group C (5 cases): bone powder mixed CGF gel + collagen membrane + CGF membrane; Group D (5 cases): bone powder + CGF membrane. Extraction and site preservation surgery were performed by the same physician and clinical follow-up was more than 6 months after surgery. The four groups will be compared on several variables, including the changes in pain score, Landry wound healing index, membrane exposure area, keratinized gingival width, buccolingual gingival width, alveolar crest width and height.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
20
Fill the extraction socket with Bio-Oss® bone powder, and cover the extraction wound with Bio-Gide® collagen membrane.
Fill the extraction socket with Bio-Oss® bone powder, and cover the extraction wound with Bio-Gide® collagen membrane plus CGF membrane(CGF gel is pressed into a film)
Fill the extraction socket with Bio-Oss® bone powder mixed with CGF gel (CGF gel is cutted into granules ), and cover the extraction wound with Bio-Gide® collagen membrane plus CGF membrane(CGF gel is pressed into a film)
The Fourth Affiliated Hospital Zhejiang University School of Medicine
Yiwu, Zhejiang Procince, China
RECRUITINGthe width of keratinized gingiva
the width of keratinized gingiva measured by periodontal probe
Time frame: preoperative, 3 months and 6 months after surgery
the horizontal width (from buccal to lingual at the alveolar top ) of gingiva
the horizontal width of gingiva measured by periodontal probe
Time frame: immediate , 3 months and 6 months postoperative
the horizontal bone resorption of alveolar crest
Compared with immediate postoperative, the horizontal width of alveolar crest decreased at 3months and 6 months, postoperative alveolar bone resorption progressed with time
Time frame: immediate , 3 months and 6 months postoperative
the vertical bone resorption of alveolar crest
the vertical width of alveolar crest decreased at 3months and 6 months postoperative compared with the immediate postoperative
Time frame: immediate , 3 months and 6 months postoperative
the average gray value of alveolar bone
the average gray value of alveolar bone
Time frame: immediate , 3 months and 6 months postoperative
Landry wound healing index
scores:1,2,3,4,5 according to the gingival healing status
Time frame: 7 days and 12 days after surgery
reduction in membrane exposure area
membrane exposure area reduce different in four groups
Time frame: 7 days,12 days and one month after surgery
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Fill the extraction socket with Bio-Oss® bone powder and cover the extraction wound with CGF membrane(CGF gel is pressed into a film)
pain score
scores: 2,4,6,8,10 using the Wong-Baker facial pain scale revision (FPS-R)
Time frame: 1day, 3days after surgerys