A Study to Assess the Safety of BMS-984923 Compared to Placebo, in People With Parkinson's

Inclusion Criteria: 1. Men or women between the ages of 50 and 80 years, inclusive at the time of screening. 2. Clinical diagnosis of Parkinson's disease as defined by the United Kingdom Parkinson's disease (PD) Society Brain Bank Clinical Diagnostic Criteria and Movement Disorder Society Parkinson's disease Criteria (must meet both criteria); must include bradykinesia and responsiveness to levodopa. 3. Maintenance on stable Parkinson's disease therapy for at least 28 days prior to Screening/Visit 1 through treatment period to Day 42, with demonstratable medication efficacy as assessed by the Investigator. 4. Severity of Parkinson's disease symptoms assessed by Hoehn and Yahr Staging score ≤3.0 (assessed in the "ON" state). 5. Maintenance on permitted stable non-Parkinson's disease therapy for at least 28 days prior to Day 1 through the treatment period to Day 42. 6. Female participants of childbearing potential must have a negative urine pregnancy test at Screening and baseline, as well as be non-lactating and must agree to use a highly effective method of contraception during the study and for 30 days following last dose of study drug. 7. Male participants must be sterile or sexually inactive or agree not to father a child during the study and for 1 month after the last dose of study medication and must agree to use a barrier method for contraception. Female partners of male subjects must adopt a highly effective method of contraception 8. Adequate visual, hearing, cognitive and physical ability and willingness to comply with study drug administration, scheduled visits, treatment plan, laboratory tests, and other study-related procedures to complete the study 9. Institutional Review Board/Ethics Committee-approved consent form signed and dated by the participant Exclusion Criteria: 1. Diagnosis of secondary or atypical parkinsonism 2. Severe or disabling fluctuations or dyskinesias that would, in the opinion of the Investigator, interfere with completion of the study 3. Previous surgical procedure for Parkinson's disease (e.g. Duopa, deep brain stimulation) 4. Clinically significant cognitive impairment with a Montreal Cognitive Assessment score \<18 5. Has a history or current evidence of long QT syndrome 6. Has bradycardia or tachycardia on the electrocardiogram (ECG) at Screening 7. Clinical or laboratory findings consistent with another primary neurodegenerative disease or cognitive disorder other than Parkinson's disease, including but not limited to, frontotemporal lobar disease, Huntington's disease, progressive supranuclear palsy, multisystem atrophy, Jacob-Creutzfeld Disease, Down's syndrome, amyotrophic lateral sclerosis, seizure disorder, or other infectious, metabolic or systemic disease affecting the central nervous system including but not limited to, syphilis, present hypothyroidism, present vitamin B12 deficiency, or other laboratory abnormalities 8. Suicidality, defined as active suicidal thoughts or ideation or history of suicide attempt in previous 2 years, or, in the Investigator's opinion, at serious risk of suicide 9. Currently active major depression as determined by Beck Depression Inventory (BDI)-II score of \>19 10. Has a history or current diagnosis of a psychiatric disorder such as schizophrenia, bipolar disorder or major depression according to the criteria of the most current version of the Diagnostic and Statistical Manual of Mental Disorders. 11. Clinically significant or unstable medical condition, including uncontrolled hypertension, or significant cardiac, pulmonary, hepatic, endocrine, or other systemic disease that in the Investigator's opinion may either put the participant at risk because of participation in the study, or influence the results, or impair the participant's ability to participate in the study 12. Any disorder that could interfere with absorption, distribution, metabolism or excretion of drugs (e.g., small bowel disease, Crohn's disease, celiac disease or liver disease) 13. Hospitalization or change of chronic concomitant medication within 8 weeks prior to baseline 14. Body mass index (BMI) \>38 kg/m2 or body weight \<50 kg 15. Has uncontrolled type 1 or type 2 diabetes. A subject with glycated hemoglobin (HbA1c) levels up to 7.5% can be enrolled if the Investigator believes the participant's diabetes is under control. 16. Has moderate or severe renal disease. 17. Has cancer or has had a malignant tumor (cerebral or systemic) within the past 3 years. (Participants with stable untreated prostate cancer or treated cutaneous squamous or basal cell carcinomas are not excluded) 18. Presence or history of psychosis, including if induced by anti-parkinsonian medications at doses required to improve motor symptoms, or hallucinations not induced by medications 19. Participant is currently pregnant, breast-feeding and/or lactating. 20. History of alcohol or substance abuse or dependence within the past 2 years. 21. Suspected or known allergy to any components of the study medication; Hypromellose Sodium lauryl sulfate, Lactose monohydrate, Croscarmellose sodium, Magnesium stearate. 22. Clinically significant abnormalities in B12 or thyroid function tests (TFTs) that might interfere with the study 23. Use of anticoagulants within 30 days or 5 half-lives (whichever is greater) prior to study drug administration and for the duration of the study 24. Use of another investigational agent within 90 days or 5 half-lives (whichever is greater) prior to Screening and for the duration of the study 25. Neutropenia defined as absolute neutrophil count of \<1,500/microliter 26. Thrombocytopenia defined as platelet count \<100,000/microliter 27. Clinically significant abnormalities in screening laboratory tests, including aspartate aminotransferase, alanine aminotransferase, total bilirubin, serum creatinine. 28. Male participants with female partners of child-bearing potential who are unwilling or unable to adhere to contraception requirements specified in the protocol. 29. Use of medications with potential drug-drug interactions within 2 weeks or 5 half-lives (whichever is greater) prior to study drug administration and for the duration of the study 30. Any contraindication to DaTscan, including claustrophobia, the presence of metal (ferromagnetic) implants, a cardiac pacemaker, or allergy to iodine 31. History of a seizure disorder, if stable on medication is acceptable 32. An immediate family member (i.e., spouse, parent, child, or sibling, whether biological or legally adopted) of the Investigator, Sponsor or contract research organizations conducting the trial 33. History of Covid-19 infection within 6 weeks prior to screening. Participants with unresolved symptoms of Covid-19 infection or ongoing cognitive or other deficits attributable to post-Covid-19, that may affect participant safety or interfere with cognitive assessments, based on the Investigator's clinical judgment. 34. Unable to comply with the protocol procedures or any significant issue raised by the Investigator that may compromise participant safety or potentially interfere with study interpretation.