Triple-negative breast carcinoma is characterized by the absence of estrogen receptors, progesterone receptors, and HER2/neu receptors. Carbonic anhydrase IX (CA IX) is a tumor-associated cell surface glycoprotein that is involved in adaptation to hypoxia-induced acidosis and plays a role in cancer progression. This study aimed to investigate CA IX expression in TNBC and its relationship with treatment effect.
Tru-cut biopsy materials, sent to our hospital pathology laboratory between August 2018 and May 2023, will be examined. Invasive carcinoma cases will be evaluated according to estrogen, progesterone, and HER 2 receptor levels. Triple-negative tumor cases were isolated and those cases who underwent breast resection in our hospital after receiving neoadjuvant chemotherapy (Adriamycin, cyclophosphamide, and then paclitaxel for 4 cycles) were included in the study.
Study Type
OBSERVATIONAL
Enrollment
40
CA IX is a transmembrane protein, it exhibits cytoplasmic membrane staining. Immunohistochemically positive cells were graded as Low staining if they constituted \<10% of the total and high staining if they constituted ≥ 10% (15).
Kahramanmaraş Sütçü İmam University
Kahramanmaraş, Turkey (Türkiye)
Poor prognostic factors in patients with TNBC
Higher staining CA IX levels (≥ 10%) in TNBC patients' pathological specimens is a poor prognostic factor
Time frame: 2018-2023
The treatment success with inhibiting the CA IX enzyme levels' effectiveness
Treatment success in TNBC patients by evaluating changes in CA IX staining levels
Time frame: 2018-2023
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