Single Dose, Three-arm Study to Compare the Pharmacokinetic Similarity of MAB-22 Versus Prolia®

Inclusion Criteria: 1. Healthy male participants between 25 and 55 years of age (inclusive) on the day of signing the informed consent. 2. Have a body weight between 50.0 and 110.0 kg (inclusive) and a body mass index (BMI) between 18.0 and 32.9 kg/m2 (inclusive). 3. Have 12-lead electrocardiogram (ECG) results without clinically significant abnormal findings confirmed by the investigator. 4. Have vital sign results without clinically significant abnormal findings confirmed by the investigator, including but not limited to: 1. Resting supine systolic blood pressure \<145 mmHg and diastolic blood pressure of \<90 mmHg. 2. Heart rate 40 to 100 beats per minute (bpm). 3. Respiration rate 8 to 20 resp/min. 4. Temporal or ear temperature 35.5 to 37.6°C. 5. Oxygen saturation 95 to 100%. 5. Have physical examination results without clinically significant abnormal findings confirmed by the investigator. Exclusion Criteria: 1. Prior diagnosis of bone disease, or any condition that will affect bone metabolism such as, but not limited to: osteoporosis, osteogenesis imperfecta, hyperparathyroidism, hyperthyroidism, hypothyroidism, osteomalacia, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, current flare-up of osteoarthritis and/or gout, active malignancy, moderate to severe renal disease (defined as glomerular filtration rate \<60 mL/min), Paget's disease of the bone, recent bone fracture (within 6 months), or malabsorption syndrome. 2. Osteonecrosis of the jaw (ONJ) or risk factors for ONJ, such as invasive dental procedures (e.g., tooth extraction, dental implants, oral surgery in the past 6 months), poor oral hygiene, periodontal, and/or preexisting dental disease at the determination of the investigator. 3. Recent tooth extraction (within 6 months of the screening visit). Edentulous participants are permitted to enroll in the study, as long as the most recent tooth extraction occurred \>6 months prior to the screening visit. 4. Evidence of hypocalcemia (total calcium below the normal range \[8.5 to 10.5 mg/dL or 2.21 to 2.65 mmol/L\]) at screening. 5. Known vitamin D deficiency (defined as vitamin D \<12 ng/mL or \<30.0 nmol/L); or known intolerance to calcium or vitamin D supplements. Retest of vitamin D is allowed once. Vitamin D repletion is permitted (e.g., vitamin D supplements) with a tolerable upper intake level of 100 mcg (4000 IU) daily, at the discretion of the investigator.