Spasticity, common after a stroke, aggravates the patient's motor impairment causing pain and limitation in daily activities such as eating, dressing and walking. There are different spasticity treatments, such as botulinum neurotoxin, in the first place. Among the emerging therapies is focal extracorporeal shock wave therapy, consisting of a sequence of sonic (mechanical) impulses with high peak pressure. Systematic reviews highlighted that shock waves effectively improve lower and upper limb spasticity. Moreover, the shock waves therapeutic effect can last up to 12 weeks from the last treatment session. When used to treat stroke spasticity, the shock waves' mechanism of action is poorly detailed. On the one side, shock waves could change the physical properties of the muscular tissue (e.g. viscosity, rigidity). On the other, the shock waves produce a robust mechanical stimulation that massively activates muscle and skin mechanoreceptors (e.g. muscle spindles). This activation would modulate, in turn, the spinal (and supra-spinal) circuits involved in spasticity. To our knowledge, no study investigated the shock waves mechanism of action in stroke upper limb spasticity. Research question: do shock waves exert their therapeutic effect on spasticity by changing the muscle's physical properties or by indirectly modulating the excitability of spinal circuits? Specific aims: To investigate the mechanism of action of shock wave therapy as a treatment of upper limb spasticity after a stroke. Two major hypotheses will be contrasted: shock waves reduce hypertonia 1) by changing the muscle's physical features or 2) by changing the motoneurons excitability and the excitability of the stretch reflex spinal circuits. Shock wave therapy is expected to improve spasticity, thus improving the following clinical tests: the Modified Ashworth Scale (an ordinal score of spasticity) and the Functional Assessment for Upper Limb (FAST-UL, an ordinal score of upper limb dexterity). This clinical improvement is expected to be associated with changes in spastic muscle echotexture assessed with ultrasounds, such as an improvement in the Heckmatt scale (an ordinal score of muscle echotexture in spasticity). Clinical improvement is also expected to be associated with an improvement in the following neurophysiological parameters: a reduction of the H/Mmax ratio (an index of hyperexcitability of the monosynaptic stretch reflex circuit), a decrease in amplitude of the F waves (a neurophysiological signal reflecting the excitability of single/restricted motoneurones) and an increase of the homosynaptic depression (also known as post-activation depression, reflecting the excitability of the transmission between the Ia fibres and motoneurones). Understanding the shock wave mechanism of action will lead to a better clinical application of this spasticity treatment. If the shock waves exert their therapeutic effect by changing the muscle's physical properties, they could be more appropriate for patients with muscle fibrosis on ultrasounds. On the contrary, if the shock waves work on spasticity by indirectly acting on the nervous system's excitability, then a neurophysiology study could be used to preliminary identify the muscle groups with the most significant neurophysiological alterations, which could be the muscles benefitting the most from this treatment.
Study Type
OBSERVATIONAL
Enrollment
12
Extracorporeal Shockwave Therapy administered to the belly of spastic muscles of the upper limb.
IRCCS Istituto Auxologico Italiano
Milan, MI, Italy
M wave and H reflex recruitment curve
Recruitment curves of the Flexor Carpi Radialis muscle of both upper limbs
Time frame: At baseline, after 7, 14 and 21 days of intervention, at 28 and 84 days after the end of the intervention
H reflex post-activation depression
Post-activation depression of the Flexor Carpi Radialis H reflex of both sides
Time frame: At baseline, after 7, 14 and 21 days of intervention, at 28 and 84 days after the end of the intervention
F waves
F waves of the First Dorsal Interosseus muscles of both upper limbs
Time frame: At baseline, after 7, 14 and 21 days of intervention, at 28 and 84 days after the end of the intervention
T reflex
T reflex of the Flexor Carpi Radialis of both sides
Time frame: At baseline, after 7, 14 and 21 days of intervention, at 28 and 84 days after the end of the intervention
Upper limb dexterity measures
Functional Assessment Test for Upper Limb
Time frame: At baseline, after 7, 14 and 21 days of intervention, at 28 and 84 days after the end of the intervention
Ultrasound arm and forearm assessment
Echographic assessment of the arm and forearm muscles
Time frame: At baseline, after 7, 14 and 21 days of intervention, at 28 and 84 days after the end of the intervention
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