Optimising CMR Scan Acquisitions for Novel Equipment/Sequences in Clinical Cardiovascular Populations.

University of Leicester30 enrolled

Overview

The purpose of this study is to develop robust protocols for the optimisation of novel hardware, software and exercise equipment in the magnetic resonance imaging (MRI) environment in various cohorts with cardiovascular disease (CVD) with the first study focusing on those with established heart failure with preserved ejection fraction (HFpEF) or those at risk of or with pre-HFpEF.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Heart Failure With Preserved Ejection Fraction

Interventions

Participants will undergo a comprehensive CMR scan on either a 1.5- or 3-Tesla scannerOTHER

Participants will undergo a comprehensive CMR scan on either a 1.5- or 3-Tesla scanner

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Males or females aged \>18 years * Either a clinical diagnosis of HFpEF, be at risk of or pre- HFpEF Exclusion Criteria: * Absolute contraindication to MRI * Unable to read/understand English sufficiently to provide informed consent * Pregnancy * Unable to consent due to lack of mental capacity * Current cancer diagnosis and actively undergoing treatment * Inability to exercise on the MRI ergometer * Severe claustrophobia

Locations (1)

Glenfield Hospital

Leicester, United Kingdom

Outcomes

Primary Outcomes

To develop CMR scanning protocols which acquire the highest quality images during incremental exercise using a stepper ergometer (Ergospect Cardio-stepper).

Time frame: By end of study - 30/04/2023

Secondary Outcomes

To determine the reproducibility of the exercise CMR protocols in a test-retest reproducibility sub-study

Time frame: By end of study - 30/04/2023

To determine the optimal scan acquisition protocol for Magnetic Resonance Spectroscopy (MRS) both H+ and 31P using the phosphorous coil in each patient group.

Time frame: By end of study - 30/04/2023

To determine the reproducibility of the MRS protocols in a test-retest reproducibility sub-study

Time frame: By end of study - 30/04/2023

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.