The AT-REBOA Target Trial

Medical University of Graz44 enrolled

Overview

Temporary aortic occlusion can limit haemorrhage, can help to maintain perfusion to the heart and brain, and may be associated with improved survival. Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) potentially provides a relatively quick means of achieving this temporary control. In the past years, studies have tried to evaluate the benefit for this method with conflicting results. The previous UK-REBOA trial has not found any benefit in the intervention group and has even hinted at possible harm caused by the intervention. A major limitation of this study is the low number of interventions performed in participating trauma centres and the associated potentially insufficient experience with REBOA. The aim of this study is to evaluate the effectiveness of REBOA in a setting with already experienced providers.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hemorrhage Shock, Traumatic Cardiac Arrest Due to Trauma Polytrauma

Interventions

Eligibility

Sex: ALLMin age: 16 Years

Medical Language ↔ Plain English

Inclusion criteria: * aged, or believed to be aged, 16 years or above * confirmed or suspected life-threatening torso or lower body trauma * thought to benefit from trauma resuscitation with REBOA Exclusion criteria: * penetrating chest trauma * known or suspected pregnancy at presentation * prehospital thoracotomy * severe burns injuries.

Locations (2)

University Medical Centre Graz

Graz, Styria, Austria

Center for Medical Data Science

Vienna, Austria

Outcomes

Primary Outcomes

30-day in-hospital mortality

Time frame: 30 days

Secondary Outcomes

3-hour mortality

Time frame: 3 hours

6-hour mortality

Time frame: 6 hours

24-hour mortality

Time frame: 24 hours

90-day mortality

Time frame: 90 days

Intensive Care Unit length of stay

days

Time frame: within 6 months

Hospital length of stay

days

Time frame: within 6 months

Blood product use

amount of packed red blood cells, amount of fresh frozen plasma, amount of thrombocyte concentrates

Time frame: 48 hours

Use of whole body computed tomography

Time frame: during resuscitation care phase within 3 hours

damage control procedure performed

operation or angioembolisation

Time frame: during resuscitation phase within 3 hours

Time to damage control procedure

operation or angioembolisation

Time frame: during resuscitation phase within 3 hours

Rate of complications

acute kidney injury °III, use of renal replacement therapy, arterial thrombosis or embolism, limb ischaemia, vascular injury, compartment syndrome requiring fasciotomy

Time frame: within 6 months

Cause of death

Time frame: within 6 months