The goal of this clinical trial is to compare Propofol versus Dexmedetomidine in children undergoing squint surgery. The main question it aims to answer is: • Which drug is more effective in preventing the appearance of Emergence Agitation in children after sevoflurane anesthesia in squint surgery, propofol or dexmedetomidine? Emergence agitation (EA) is a period of restlessness, agitation, inconsolable crying, disorientation, delusions, and hallucinations with impaired cognition and memory that commonly occurs in children undergoing ophthalmic surgery especially after Short acting volatile agents such as sevoflurane.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
80
After completion of the procedure and after regain muscle power sevoflurane administration will be ceased. children will be randomized to receive propofol 1mg/kg over 10 minutes (group 1) .
After completion of the procedure and after regain muscle power sevoflurane administration will be ceased. children will be randomized to receive dexmedetomidine 0.2 mcg/kg over 10 minutes (group 2).
Ain Shams University
Cairo, Cairo Governorate, Egypt
the overall incidence of postoperative Emergence Agitation
Pediatric Anesthesia Emergence Delirium (PAED) scale will be use to assess the incidence of Emergence Agitation (EA) A PAED score of 10 or higher is considered to be diagnostic of EA, but a score of 12 or higher is more sensitive and specific.
Time frame: EA incidence and severity will be determined using (PAED) scale at extubation (E0), upon arrival to the Post Anesthesia Care Unit (PACU) E1 and after 15 minute (E2), then after 30 minute in the PACU (E3).
heart rate changes
heart rate (HR) will be measured at extubation , upon arrival to the PACU and after 15 minutes , then after 30 minutes in the PACU.
Time frame: 30 minutes in the PACU
mean arterial pressure (MAP) changes
mean arterial pressure (MAP) will be measured at extubation , upon arrival to the PACU and after 15 minutes , then after 30 minutes in the PACU.
Time frame: 30 minutes in the PACU
peripheral oxygen saturation (SpO2) changes
peripheral oxygen saturation (SpO2) will be measured at extubation , upon arrival to the PACU and after 15 minutes , then after 30 minutes in the PACU.
Time frame: 30 minutes in the PACU
Proportion of patients with adverse events in the PACU
including oxygen desaturation defined as SpO2 \< 90%, regarded as severe desaturation when SpO2 \< 85%, bradycardia defined as HR \< 80 beats/min , shivering, dizziness, laryngospasm, severe coughing, and reintubation.
Time frame: assessed up to 30 minutes after arrival of patient to PACU.
Proportion of patients with Post Operative Nausea and Vomiting (PONV)
evaluated by a 4-point PONV Scale .
Time frame: assessed up to 30 minutes after arrival of patient to PACU.
Time to discharge from the PACU.
the time the patients needs to be stable and discharge from the PACU
Time frame: 60 minutes
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