The patients with cognitive impairment after stroke were divided into control group, electroacupuncture group, olfactory therapy group, electroacupuncture combined with olfactory therapy group, and sham group with 35 people in each group. After the end of the treatment, the clinical efficacy was evaluated.
The patients with cognitive impairment after stroke were divided into control group, electroacupuncture group, olfactory therapy group, and electroacupuncture combined with olfactory therapy group, and sham group with 35 people in each group. All patients were treated with conventional drugs and general supportive treatment, and on the basis of this, the electroacupuncture group was given electroacupuncture treatment at bilateral Fengchi and Gongxue, the smell suction therapy group was given the intervention of volatile oil nasal suction of Acorus calamus, and the electroacupuncture group combined with smell and suction therapy group was given electroacupuncture treatment at the same time as the electroacupuncture treatment of bilateral Fengchi and Gongxue. In the sham stimulation group, non-transdermal comfortable acupuncture will be used to make the patients experience a feeling similar to acupuncture. After the 1 month innervation,the main efficacy indicators: Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Barthel Index (MBI) score, and the secondary efficacy indicators: Transcranial Doppler (TCD), near-infrared functional brain imaging , magnetic resonance examination, the heart rate,blood pressure and the State Trait Anxiety Inventory (STAI)are collected.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
220
Donepezil hydrochloride was administered at 5 mg once a day (nightly) for 30 days without adverse reactions and then increased to 10 mg once a day (nightly) for 4 weeks.
Electronuchal acupuncture
nasal suction intervention with volatile oil of Acorus calamus
the Affiliated Zhejiang Provincial People's Hospital to Hangzhou Medical College.
Hangzhou, Zhejiang, China
RECRUITINGMoCA
Montreal Cognitive Assessment Scale
Time frame: 0,4 weeks after the intervention, 8 weeks after the intervention
MMSE
Mini-Mental State Examination
Time frame: 0,4 weeks after the intervention,8 weeks after the intervention
MBI
Barthel index score
Time frame: 0,4 weeks after the intervention,8 weeks after the intervention
TCD
Transcranial Doppler examination
Time frame: 0,4 weeks after the intervention
Near-infrared functional imaging of the brain
Near-infrared functional imaging of the brain
Time frame: 0,4 weeks after the intervention
Magnetic resonance scanning
Magnetic resonance scanning
Time frame: 0,4 weeks after the intervention
the State Trait Anxiety Inventory (STAI)
the State Trait Anxiety Inventory (STAI)
Time frame: 0,4 weeks after the intervention
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On the basis of electric nuchal acupuncture treatment, sniffing and inhalation therapy is given.
In the sham stimulation group, non-transdermal comfortable acupuncture will be used to make the patients experience a feeling similar to acupuncture.