This is a prospective observational study collecting long-term clinical data and samples for research in pediatric inflammatory bowel disease (IBD) patients with gut inflammation and a control cohort of pediatric patients with disorders of the brain-gut interactions (DBGI) with no detectable gut inflammation.
Research procedures will coincide with clinical visits at institutional standards. As part of their clinical disease evaluation, participants will have blood, stool, and tissue collected as indicated by their disease course. Additional research samples or data will be collected during these visits. Participants will be asked to collect urine samples specifically for research.
Study Type
OBSERVATIONAL
Enrollment
200
Esophagogastroduodenoscopy (EGD) is a test procedure to examine the lining of the esophagus, stomach, and first part of the small intestine.
Colonoscopy is a test procedure to examine the lining of the different portions of the large intestine: cecum, colon, rectum, and anal canal.
Seattle Children's Hospital
Seattle, Washington, United States
RECRUITINGBio-repository sample collection for spatial transcriptomics
Collection of blood and stool samples at baseline month 1, month 2, month 3, month 6, month 12, month 24, and month 36. Tissue will be collected at baseline and at any follow-up endoscopy or surgical intervention.
Time frame: 3 years
Paris Classification of Crohn's Disease
* Age at diagnosis * Location of disease: distal 1/3 +- ileum limited cecal disease, colonic, ileocolonic, upper disease proximal to ligament of treitz, upper disease distal to ligament of treitz and proximal to distal 1/3 ileum * Behavior of disease: non-stricturing/non-penetrating, stricturing, penetrating, both penetrating and stricturing disease, either at the same or different times * Perianal sub type: yes, no, do not know * Growth sub type: no evidence of growth delay, growth delay
Time frame: Baseline
Montreal Classification of Crohn's disease
* Age at diagnosis * Location of disease: terminal ileal +- limited cecal disease, colonic, ileocolonic, isolated upper disease * Behavior of disease: non-stricturing/non-penetrating, stricturing, penetrating, both penetrating and stricturing disease, either at the same or different times
Time frame: Baseline
Paris Classification of Ulcerative Colitis/Indeterminate Colitis
* Extent of disease: ulcerative proctitis, left-sided UC (distal to splenic flexure), extensive (hepatic flexure distally), pancolitis (proximal to hepatic flexure) * Severity: never severe, ever severe
Time frame: Baseline
Montreal Classification of Ulcerative Colitis/Indeterminate Colitis
* Extent of disease: ulcerative proctitis, left-sided UC (distal to splenic flexure), extensive (proximal to splenic flexure) * Severity: clinical remission, mild UC, moderate UC, severe UC
Time frame: Baseline
Disorder of Gut-Brain Interaction classification
Diagnoses super-type and applicable sub type: * Esophageal Disorders * Gastroduodenal Disorder * Bowel Disorder * Centrally Mediated Disorders of GI Pain * Gallbladder and Sphincter of Oddi Disorder * Anorectal Disorder * Childhood Functional GI Disorders: Neonate/Toddler * Childhood Functional GI Disorders: Child/Adolescent
Time frame: Baseline
Physician's Global Assessment (PGA)
Severity: Quiescent, Mild, Moderate, Severe
Time frame: 3 years
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