Circulating Factors in Nephrotic Syndrome

N/ANot Yet RecruitingNCT06315504

Iain Bressendorff104 enrolled

Overview

A prospective observational study to investigate the treatment-associated changes of circulating factors associated with glomerular diseases among patients with de novo nephrotic syndrome admitted to hospital for a kidney biopsy.

Study Type

OBSERVATIONAL

Enrollment

104

Conditions

Nephrotic Syndrome Membranous Nephropathy Minimal Change Disease Primary Focal Segmental Glomerulosclerosis

Interventions

ObservationOTHER

Observation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 18 years * Plasma albumin \< 36 g/L * Urine protein \>3.5 g/day or urine protein/creatinine-ratio (UPCR) \> 3.5 or urine albumin/creatinine-ratio (UACR) \>2200 mg/g * Planned kidney biopsy * Able to give written informed consent Exclusion Criteria: * Kidney transplant recipient * Previously undergone a kidney biopsy * Unable to understand written information in Danish

Outcomes

Primary Outcomes

levels of anti-nephrin in blood by ELISA

temporal association of anti-nephrin with clinical remission of nephrotic syndrome

Time frame: up to 12 months

Secondary Outcomes

changes in auto-antibodies in blood associated with membranous nephropathy

temporal association of auto-antibodies with clinical remission of nephrotic syndrome

Time frame: up to 24 months

Central Contacts

Iain Bressendorff, MD PhD

CONTACT

+4524277139 iain.oshoej.bressendorff@regionh.dk

Ditte Hansen, MD PhD

CONTACT

+4538682056 ditte.hansen.04@regionh.dk

Data from ClinicalTrials.gov

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