Prospective Randomized Controlled Clinical Trial to Compare Intrathecal Dexmedetomidine Versus Midazolame in Orthopedic Cancer Surgeries
Comparison of intrathecal dexmedetomidine plus Bupivacaine vs intrathecal midazolam plus Bupivacaine on duration of sensory and motor blockade and hemodynamic parameters of patients
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
75
5 micrograms intrathecal dexmedetomidine
2 milligrams intrathecal midazolam
12.5 milligrams 0.5% intrathecal hyperbaric bupivacaine
National cancer institute
Cairo, Egypt
Duration of sensory block
Duration of sensory block after spinal anesthesia by the ability of the patient to demonstrate the pinprick sensation
Time frame: 12 hours
Incidence of vomiting occurrence
The patient will be reported in case of vomiting occurrence
Time frame: 12 hours
Sedation
Ramsay's sedation score1: anxious, agitated and restlessness, 2: oriented and cooperative, 3: responds to command only, 4: brisk response to loud voice and light glabellar tap, 5: sluggish to no response to light glabellar tap or loud auditory stimulus, 6: no response even to pain
Time frame: 12 hours
Change in mean arterial blood pressure
Non invasive blood pressure measurement
Time frame: 12 hours
Duration of motor block
Ability of patient to regain full motor power
Time frame: 12 hours
Change in heart rate
Heart rate will be compared between the three groups and will be compared with baseline preoperative values in each group
Time frame: 12 hours
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