Outcomes Comparison Between Bone Resection and Subperiosteal Dissection for Specific Type of Soft Tissue Sarcoma

Second Affiliated Hospital, Zhejiang University, School of Medicine142 enrolled

Overview

the purpose of this study is to assess whether bone resection for thigh soft tissue sarcoma with cortical involvement of the adjacent bone result in better local control and survival compared to sub-periosteal dissection. Investigators also aim to find out the prognostic factors for clinical outcomes in this group of patients.

Study Type

OBSERVATIONAL

Enrollment

142

Conditions

Soft Tissue Sarcoma Cortical Contact

Interventions

bone resectionPROCEDURE

patients underwent soft tissue sarcoma excision together with bone resection following either biological or endoprosthesis reconstruction

subperiosteal excisionPROCEDURE

patients underwent sub-periosteal tumor excision combining bone and soft tissue ablation without bone excision

Eligibility

Sex: ALLMin age: 8 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients developed thigh soft tissue sarcoma, defined as lesion located below the plane of the lesser trochanter and above the plane of the femoral condyle. 2. received primary limb-salvage surgery at our center. 3. soft tissue sarcoma with only cortical contact of the adjacent bone based on preoperative imaging 4. minimum of 2-year follow up Exclusion Criteria: 1. diagnosis was well differentiated liposarcoma 2. patients with metastatic disease at the time of presentation 3. soft tissue sarcoma displayed frank osseous invasion (eg. medullary canal invasion)

Outcomes

Primary Outcomes

survival

Whether patient die or not

Time frame: patients were checked every three months for the initial two years after surgery and every 6 months for the subsequent three years. After 5 years, patients will be checked once every year until patients died or were loss to follow up.

recurrence

whether patients developed local recurrence

metastasis

whether patients developed metastasis

Secondary Outcomes

functional outcomes

The Musculoskeletal Tumor Society (MSTS) questionnaire for the lower extremity is composed of six items including pain, function, emotional acceptance, use of any external support, walking ability, and gait alteration. Each item is rated in a scale of 0-5. The total score ranges from 0 to 30, with higher scores indicating better function.

Time frame: MSTS scores were measured every 6 months for the first two years after surgery. After that, MSTS outcomes were measured once every year until patients died or were loss to follow up.

Data from ClinicalTrials.gov

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