A prospective randomized controlled study compared the effects of perioperative immunonutrition and standard enteral nutrition (EN) on postoperative short-term outcomes of patients with head and neck (HNC). Five days before surgery and the postoperative day 10, immunonutrition support was given to the intervention group (n=17), and standard EN support was given to the control group (n=17). Body analyses were made, food consumption records were taken, NRS-2002 and quality of life scales were applied, and biochemical parameters were recorded.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
34
Immunonutrition was given to the patients in the intervention group and ready-to-use liquid in addition to their normal nutrition 5 days before the operation. The patients were instructed to consume three enteral products per day as taken between meals. In the postoperative period, feeding was started in the first 24 hours with the NG tube placed during the operation. The ready-to-use immunonutrition product was given to the patients in the intervention group.
Standard enteral nutrition was given to patients in the control group in addition to their normal nutrition 5 days before the operation. The patients were instructed to consume three enteral products per day between meals. In the postoperative period, feeding was started in the first 24 hours with the NG tube placed during the operation. Liquid standard enteral nutrition was given to the patients in the control group.
Erciyes University
Talas, Kayseri, Turkey (Türkiye)
Body weight
Kg
Time frame: 40 days
Body weight loss
Kg
Time frame: 40 days
Body mass index
kg/m2
Time frame: 40 days
Resting metabolic rate
kcal
Time frame: 40 days
Nutrition Risk Screening 2002
A total score of ≥3 indicates that the patient is at nutritional risk
Time frame: 40 days
The EORTC Core Quality of Life questionnaire-30 (EORTC QLQ-C30)
1. Estimate the average of the items that contribute to the scale; this is the raw score. 2. Use a linear transformation to standardise the raw score, so that scores range from 0 to 100; a higher score represents a higher ("better") level of functioning, or a higher ("worse") level of symptoms.
Time frame: 40 days
The EORTC Quality of life - Head and Neck Cancer Module (EORTC QLQ-H & N35)
The head \& neck cancer module incorporates seven multi-item scales that assess pain, swallowing, senses (taste and smell), speech, social eating, social contact and sexuality. There are also eleven single items. For all items and scales, high scores indicate more problems (i.e. there are no function scales in which high scores would mean better functioning).
Time frame: 40 days
Albumin
g/dL
Time frame: 40 days
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C-reactive protein
mg/L
Time frame: 40 days
Prealbumin
mg/dL
Time frame: 40 days
Length of hospital stay
days
Time frame: 40 days
Complication development status
It was evaluated as yes/no.
Time frame: 40 days