Lymph nodes are very important immune organs in the human body and play an important role in the physiological and pathological activities of the body, especially in anti-tumor immunity. The role of regional draining lymph nodes in the development of colorectal cancer is still unknown. In this study, the role of lymph nodes in the development of colorectal cancer was investigated through multicenter and multi-omics data.
Study Type
OBSERVATIONAL
Enrollment
500
To investigate the difference of immune pathway activation in tumor-draining lymph node based on genomics
BULK-RNA sequencing was performed on tumor draining lymph nodes to detect the activation of immune pathways in lymph nodes and explore the differences between them
Time frame: 2024.04-2026.04
To investigate the relationship between the type and number of immune cells in tumor draining lymph nodes and the activation of immune pathways is based on pathomics
Multiple immunohistochemistry was used to identify the type and number of immune cells and to explore the relationship between the activation state of immune pathways
Time frame: 2024.04-2026.04
The immune function of tumor draining lymph nodes of colorectal cancer patients was previously identified based on radiomics
Preoperative imaging data (CT, MRI) of patients were collected, and information in the images was extracted based on artificial intelligence algorithms. Predictive models were constructed to identify patients with good or bad immune function before surgery and guide subsequent treatment
Time frame: 2024.04-2026.04
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.