The goal of this clinical trial is to test in Rheumatoid arthritis. The main question it aims to answer are: * To verify the effect of dietary fiber supplementation on reducing the level of inflammation; * To verify the effect of dietary fiber supplementation on improving disease activity and quality of life in patients with rheumatoid arthritis .To verify the effect of dietary fiber supplementation on regulating the production of anti-inflammatory short-chain fatty acid in the gut of patients with rheumatoid arthritis. The experimental group was supplemented with dietary fiber for 12 weeks, and the control group was fed with the Mediterranean diet. Before and after the intervention, 1 tube of 3ml blood and 1 soybean-sized stool were taken and a questionnaire was made
Rheumatic arthritis (RA) is caused by chronic inflammation and joint injury caused by imbalance of pro-and anti-inflammatory mediators in the joints. Studies have shown that dietary fiber (DF) can be fermented by gut bacteria into anti-inflammatory short-chain fatty acid that may reduce joint inflammation, relieve symptoms and improve quality of life. The subjects were Randomized controlled trial to supplement DF12W individually, the intervention group to supplement DF12W, and the control group to supplement DF12W with routine diet, the differences of disease activity (DAS28 score) , inflammatory markers (TNF-a, IL-6, Mir-146a, Treg, ESR, CRP, etc.) and quality of life (SF-36) between the two groups were compared. The changes of intestinal flora were examined to verify the hypothesis. This study laid a good scientific foundation for dietary recommendation of RA patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
25
Dietary fiber, known as the "seventh type of nutrients," refers to carbohydrate polymers that have health benefits for the human body, mainly derived from plant cell walls such as grains, fruits, and vegetables.Mediterranean cuisine is a dietary pattern
Jingjing Li
Shenzhen, Guangdong, China
Disease activity score
Questionnaire evaluation,Higher scores mean worse results
Time frame: 12 weeks
Quality of life score
Health Assessment Questionnaire,Higher scores mean worse results
Time frame: 12 weeks
Compliance of oat bran
Use the follow-up record table to record the patients were followed up weekly on how many packets they ate . One pack a day, up to 7 packs a week, the greater the number, the better the compliance
Time frame: 12 weeks
Inflammatory indicators :TNF- α
Inflammatory factors were detected by ELISA ,In pg/ml.
Time frame: 12 weeks
Inflammatory indicators:IL-6
Inflammatory factors were detected by ELISA ,In pg/ml.
Time frame: 12 weeks
Inflammatory indicators :IL-10
Inflammatory factors were detected by ELISA ,In pg/ml.
Time frame: 12 weeks
Inflammatory indicators: ESR
Inflammatory factors were detected by Weiss method,In mm/h.
Time frame: 12 weeks
Inflammatory indicators :CRP
Inflammatory factors were detected by One-way immunodiffusion assay,In mg/L
Time frame: 12 weeks
gut flora
Metagenesis is used to detect intestinal flora, InTags Per Million
Time frame: 12 weeks
Adjustment of anti rheumatic drugs
The increment and decrement are unchanged.Incremental means going from not taking a synthetic anti-rheumatic drug to taking a synthetic anti-rheumatic drug, or increasing the dose of the original drug, or increasing the type of drug, or from the original traditional synthesis of disease-improving anti-rheumatic drugs adjusted for the biological synthesis of disease-improving anti-rheumatic drugs. A reduction in the dose of a synthetic anti-rheumatic drug is defined as a reduction in the dose of a synthetic anti-rheumatic drug from taking it to discontinuing it, or a reduction in the dose of the original drug, or from the original bio-synthesis to improve the condition of anti-rheumatic drugs adjusted to traditional synthesis to improve the condition of anti-rheumatic drugs
Time frame: Week 12
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