Brain Mechanisms of Reducing Polysubstance Use

Arizona State University35 enrolled

Overview

The proposed study will test whether neurofeedback (NF) could optimize integrative body-mind training (IBMT) practice.

The proposed study will test whether real-time NF could optimize IBMT practice and improve effects in reducing polysubstance use through targeting self-control networks in the brain.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Multiple Drug Use

Interventions

IBMTBEHAVIORAL

IBMT is an effortless mindfulness technique

NFBEHAVIORAL

NF is a mental training technique.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * At least 18 years old * Free of any psychiatric diagnoses or medication (besides a substance use disorder (SUD) to alcohol, tobacco, or cannabis) * In the past month, at least 4 episodes of heavy episodic drinking; at least 3 occasions of cannabis use; and daily cigarette use for at least the past month * Normal or corrected-to-normal vision * Written informed consent * No previous meditation or NF experiences Exclusion Criteria: * Any psychiatric diagnoses other than an SUD * Medical disorder(s) that may affect the central nervous system; medications that affect the central and autonomic nervous system; or a positive pregnancy test result (females) * Excluding cannabis, evidence of recent (past month) illicit drug use

Locations (1)

YiYuan Tang

Phoenix, Arizona, United States

RECRUITING

Outcomes

Primary Outcomes

Intervention effects on brain function using Functional Magnetic Resonance Imaging (fMRI)

Brain connectivity changes such as anterior and posterior cingulate cortex measured by fMRI resting state imaging

Time frame: The outcome measures are assessed in-person at baseline, 2-4 weeks and 3 months

Intervention effects on brain white matter using fMRI

Brain white matter changes such as anterior and posterior cingulate cortex measured by fMRI diffusion tensor imaging

Time frame: The outcome measures are assessed in-person at baseline, 2-4 weeks and 3 months

Intervention effects on brain grey matter using fMRI

Brain volume changes such as anterior and posterior cingulate cortex measured by fMRI structural imaging

Time frame: The outcome measures are assessed in-person at baseline, 2-4 weeks and 3 months

Secondary Outcomes

Intervention effects on addiction behavior using substance use questionnaires in PhenX Toolkit

Intervention leads to a significant reduction in craving and substance use measured by substance use questionnaires in PhenX Toolkit

Time frame: The outcome measures are assessed in-person at baseline, 2-4 weeks and 3 months

Central Contacts

YiYuan Tang

CONTACT

4807903577 yiyuan@asu.edu

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.