In'Oss™ (MBCP® Putty) Ortho

Inclusion Criteria: 1. Patient is male or female, 18 - 85 years old; 2. Patient is willing and able to give written informed consent; 3. Patient is able to comply with a prior medical examination; 4. Patient is or has been scheduled for a surgical procedure to correct epiphyso-metaphyseal and/or metaphyso-diaphyseal bone defect in one of the following anatomical locations: * Proximal humerus ▪ Distal radius * Distal femur ▪ Proximal tibia ▪ Distal tibia 5. Patient is willing and able to comply with the study procedures during surgery and the post-surgical follow up period, up to 12 months. Exclusion Criteria: 1. Patient has had an infection in the same extremity within last 24 months; 2. Patient has signs of necrosis at the surgical site; 3. Patient has cellulitis; 4. Patient has granuloma or non-curetted cyst; 5. Patient has an history of uncontrolled diabetes; 6. Patient is alcoholic and/or heavy smoker (\> 20 cigarettes per day); 7. Patient has a congenital or acquired immunodeficiency; 8. Patient has severe bone loss (≥ 40cm3); 9. Patient is on long-term steroidal therapy or treatment acting on the calcium or phosphorus metabolism; 10. Patient is or has been scheduled for surgery that would involve intra-articular implantation of the study device; 11. Patient who has or had an uncontained bone defect created as a result of trauma injury or surgically created; 12. Patient was exposed to any radiation (e.g. X-Rays, handling of radiolabelled materials) other than the normal background radiation within the 12 months before the screening visit; 13. Patient is pregnant; 14. Patient who is an employee at the study site; 15. Patient is known to be non-compliant with medical treatment or follow-up 16. Patient has any significant or unstable medical/psychiatric condition that, in the opinion of the Investigator, would interfere with their ability to participate in the study; 17. Patient is currently enrolled or planning to enrol in another clinical study or treatment with another investigational drug/device that may interfere with the assessments, visits or outcomes of this study.