Neuroendocrine Mechanisms in Adiposity: An Integrated Approach to the Characterization of Potential Pharmacological Novel Targets Based on Experimental and Clinical Models

N/ANot Yet RecruitingNCT06326853

IRCCS San Raffaele200 enrolled

Overview

The goal of this observational study is to evaluate, retrospectively and prospectively, the effect of different hormonal and neuropeptide dysfunctions on the body composition of patients suffering from hypothalamic-pituitary pathologies, and to evaluate the potential beneficial effect of surgical and medical treatments with agonists and antagonists of hypothalamic neuropeptides, currently available, on the development and treatment of adiposity and negative cross-talk between adiposity and muscle/bone tissue

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Endocrine Disorders Adiposity Pituitary Adenoma Cushing Syndrome Acromegaly Hypopituitarism

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: Obese patients affected and not by hypothalamic-pituitary diseases Exclusion Criteria: 1. Minor subjects; 2. Pregnant and/or breastfeeding women; 3. Patients suffering from states of primary and/or acquired immunodeficiencies, and/or serious impairment of general clinical conditions (e.g. metastatic neoplasms; immunosuppressive therapies; worsening/reacerbated/compensated chronic pathologies); 4. Patients unable to understand and sign the Informed Consent.

Outcomes

Primary Outcomes

Rate of patients with BMI greater than 30 with hypothalamic-pituitary pathologies

The study aims to evaluate, retrospectively and prospectively, the effect of different hormonal and neuropeptide dysfunctions on the body composition of patients suffering from hypothalamic-pituitary pathologies

Time frame: retrospective and prospective collection of clinical data between 01/01/2021 and 31/12/2026