This study aims to compare the postoperative outcomes of low rectal cancer patients who underwent surgery with Natural Orifice Specimen Extraction (NOSE) versus traditional Pfannenstiel extraction.
Natural Orifice Specimen Extraction (NOSE) in colorectal surgery allows the extraction of the surgical specimen through the anal orifice. Several studies demonstrated improved postoperative pain, bowel movements, patient-reported cosmetic satisfaction, and psychological wellbeing after NOSE compared with traditional Pfannenstiel extraction. However, most of these studies focused on colon surgery. The aim of this retrospective propensity score matched study is to investigate the postoperative outcomes of NOSE in low rectal cancer surgery, classified according to the English National Low Rectal Cancer Development Programme (LOREC).
Study Type
OBSERVATIONAL
Enrollment
350
Low rectal cancer resection with Total Mesorectal Excision (TME) and Natural Orifice Specimen Extraction (NOSE)
Low rectal cancer resection with Total Mesorectal Excision (TME) and specimen extraction through Pfannenstiel incision
IRCCS Humanitas Research Hospital
Rozzano, MI, Italy
RECRUITINGSurgical Site Infections (SSI)
Rate difference of 30-day Surgical Site Infections (SSI)- defined according to the definition of the Center for Disease Control and Prevention (CDC) \[Ref\]- between the study cohorts.
Time frame: 30 days after surgery
Opioid rescue
Difference in the proportion of patients requiring opioid rescue during the hospitalization
Time frame: From the date of surgery to the date of discharge
Postoperative pain
The median difference of 72-hour patient-reported pain- measured on the Visual Rating Scale (VRS)
Time frame: 72 hours after surgery
Postoperative ileus
Rate difference of 30-day postoperative functional ileus (define as the absence of bowel function for at least three days)
Time frame: 30 days after surgery
Incisional hernia
The rate difference of six-month incisional hernia
Time frame: 6 months after surgery
Overall postoperative complications
The rate difference of overall 30-day postoperative complications, classified according to the Clavien-Dindo scale \[ranging from 0 (no complications) to 5 (complications leading to death)\]
Time frame: 30 days after surgery
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