The goal of this observational study is to evaluate the long-term effect of DBS-STN on cognitive and behavioral outcomes in Parkinson's disease (PD) patients. PD patients will be assessed over time using tests, questionnaires and standardized clinical scales. An initial assessment (T0) and annual follow-up assessments will be carried out for 5 years. Researchers will compare data collected from patients with DBS versus patients with best medical therapy.
Study Type
OBSERVATIONAL
Enrollment
52
Psychometric assessment of cognitive and behavioral outcomes
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, Lombardy, Italy
RECRUITINGLong-term characterization of DBS-STN on cognitive outcomes
Cognitive impairment change from baseline until 5 years in Montreal Cognitive Assessment (MoCA; min. 0, max. 30, higher score means better outcome) \[Time Frame: Annual assessments up to 5 years\]
Time frame: Annual assessments up to 5 years
Beck Depression Inventory
Depressive symptoms change from baseline to 5 year (BDI-II, min 0, max 63, higher score means worse outcome)
Time frame: Annual assessments up to 5 years
State-Trait Anxiety Inventory
Anxiety symptoms change from baseline to 5 year (STAI, min 20, max 80, higher score means worse outcome)
Time frame: Annual assessments up to 5 years
Questionnaire for Impulsive-Compulsive Disorders in Parkinson
Impulsivity change from baseline to 5 years (QUIP, min 0, max 112, higher score means worse outcome)
Time frame: Annual assessments up to 5 years
Pittsburgh Sleep Quality Index
Sleep Quality change (PSQI, min 0, max 21, higher score means poorer sleep quality)
Time frame: Annual assessments up to 5 years
Parkinson's Disease Questionnaire-8
Quality of life change from baseline to 5 years (PDQ-8, min 0, max 100, higher score means worse outcome)
Time frame: Annual assessments up to 5 years
Minnesota Multiphasic Personality Inventory 2-RF
Personality change from baseline to 5 years (MMPI-2-RF, cut-off: T\>65 for clinical scales)
Time frame: Annual assessments up to 5 years
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