This study is being conducted to evaluate efficacy parameters (disease free survival \[DFS\] and overall survival \[OS\]) of atezolizumab and atezolizumab in combination with tiragolumab in TMB-H or MSI-H as adjuvant treatment after standard radical intended treatment in participants with intermediate-high risk of recurrence.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
A dose of 1680 mg atezolizumab will be administered intravenously on Day 1 of each 28-day cycle for a total of 12 cycles.
A dose of 840 mg tiragolumab will be administered intravenously on Day 1 of each 28-day cycle for a total of 12 cycles.
Hospital Universitari Vall dHebron; Oncology
Barcelona, BARCELONA, Spain
Hospital Universitario 12 de Octubre; Servicio de Oncologia
Madrid, Madrid, Spain
Hospital Universitario Virgen; Servicio de Oncologia
Seville, SEVILLA, Spain
Disease Free Survival (DFS) Rate at 24 Months
Time frame: Month 24
DFS Rate at 36, 48 and 60 Months
Time frame: Months 36, 48, 60
OS (Overall Survival)
Time frame: From randomization to death from any cause (up to approximately 60 months)
Percentage of Participants With Adverse Events
Time frame: Up to approximately 60 months
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