NIV Versus HFO Versus Standard Therapy Immediately After Weaning From Mechanical Ventilation in ARDS Patients

Northern State Medical University60 enrolled

Overview

The weaning failure is a paramount challenge when aggressive discontinuation of respiratory support in ARDS. The aim of the study is to improve weaning safety and efficacy by a transient postextubation non-invasive respiratory support.

HFNO (high-flow nasal oxygenation and NIV (non invasive ventilation) are to be randomly compared in the ARDS postextubation period.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Mechanical Ventilation Complication Weaning Failure Acute Respiratory Distress Syndrome High-flow Oxygenation

Interventions

Respiratory supportDEVICE

High-flow nasal oxygenation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: ARDS Exclusion Criteria: Severe ICU-aquired weakness Severe COPD

Locations (1)

City hospital # 1

Arkhangelsk, Arkhangelskaya oblast, Russia

Outcomes

Primary Outcomes

Weaning failure

Weaning failure and re-intubation or recanulation

Time frame: 48 hrs

Data from ClinicalTrials.gov

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