The aim of the present study is to ask women treated with adjuvant or neoadjuvant chemotherapy for breast cancer what survival benefit would justify the treatment. The benefit should be evaluated in terms of Survival rate trade off and Survival time trade off value. The analyses will be conducted into three different groups of patients to value the survival benefit expected: 1. before to start the chemotherapy 2. during chemotherapy 3. after the end of chemotherapy
The chemotherapy is generally proposed a large number of early breast cancer patients to reduce the risk of recurrence and death. However chemotherapy is associated with side effects that impact the quality of life of the patients. Patients are more likely to accept treatment on the basis of presented relative rather than absolute risks and so the question arises as to whether unrealistic improvements in outcome are expected by patients. The interviews with patients in the proposed trial will elicit the expected gains both in terms of survival and life years and will be able to assess the proportion of patients who considered an improvement of realistic size was sufficient to justify the treatment.
Study Type
OBSERVATIONAL
Enrollment
450
Completion of questionnaires at the time of study entry
European Institute of Oncology
Milan, Italy
RECRUITINGPercentage of risk reduction needed to consider adjuvant or neoadjuvant chemotherapy worthwhile
Risk reduction will be evaluated in the 40% and 20% 5 years risk scenarios
Time frame: 1 week
Prolonged survival time gain needed to consider CT worthwhile
Prolonged survival time gain will be evaluated in the 5-yr and 15-yr survival scenarios
Time frame: 1 week
Behavior assessment
Collection of CONOR questionnaire (minimum value: 0, maximum value: 5 - higher scores mean a greater agreement with the statement)
Time frame: 1 week
Reaction to uncertain situations assessment
Collection of Intolerance of Uncertainty Scale Short-Form (IUS-12) questionnaire (minimum value: 1, maximum value: 5 - higher scores mean a greater agreement with the statement)
Time frame: 1 week
Regret and disappointment assessment
Collection of Regret and Disappointment Scale (RDS) questionnaire (minimum value: 1, maximum value: 7 - higher scores mean a greater agreement with the statement)
Time frame: 1 week
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