The purpose of this study is to investigate whether norepinephrine(N), phenylephrine(P) or ephedrine(E) have different effect on cerebral oxygenation in abdominal surgery with propofol or sevoflurane.
This study was a single-center, randomized, double-blinded, controlled trial. First, the effects of E, P, or N on cerebral oxygen saturation(rScO2) under general anesthesia in abdominal surgery were studied. Patients with abdominal surgery were evaluated using near-infrared spectroscopy. Continual changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO) and systemic vascular resistance (SVR) will be measured with LiDCO rapidV3 monitoring system. To investigate the individualized therapeutic options \& specific mechanisms of the three vasopressors on rScO2 and CO.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
180
after induction of anesthesia, use total intravenous anesthesia maintained with propofol
after induction of anesthesia, use total intravenous anesthesia maintained with propofol
after induction of anesthesia, use total intravenous anesthesia maintained with propofol
Dalian Municipal Central Hospital
Dalian, Liaoning, China
RECRUITINGContinual changes in Cerebral Oxygen Saturation
This outcome is measured by near-infrared spectroscopy
Time frame: 10 minutes after entering the operating room; when 20% decrease in baseline MAP after both induction of anesthesia and intubation; when MAP rising to the highest point after administration of vasopressors
Continual changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP)
This outcome is measured by LiDCO rapidV3 monitoring system
Time frame: 10 minutes after entering the operating room; when 20% decrease in baseline MAP after both induction of anesthesia and intubation; when MAP rising to the highest point after administration of vasopressors
Continual changes in heart rate (HR)
This outcome is measured by LiDCO rapidV3 monitoring system
Time frame: 10 minutes after entering the operating room; when 20% decrease in baseline MAP after both induction of anesthesia and intubation; when MAP rising to the highest point after administration of vasopressors
Continual changes in stroke volume (SV)
This outcome is measured by LiDCO rapidV3 monitoring system
Time frame: 10 minutes after entering the operating room; when 20% decrease in baseline MAP after both induction of anesthesia and intubation; when MAP rising to the highest point after administration of vasopressors
Continual changes in cardiac output (CO)
This outcome is measured by LiDCO rapidV3 monitoring system
Time frame: 10 minutes after entering the operating room; when 20% decrease in baseline MAP after both induction of anesthesia and intubation; when MAP rising to the highest point after administration of vasopressors
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after induction of anesthesia, use inhalation anesthesia maintained with sevoflurane
after induction of anesthesia, use inhalation anesthesia maintained with sevoflurane
after induction of anesthesia, use inhalation anesthesia maintained with sevoflurane
Continual changes in systemic vascular resistance (SVR)
This outcome is measured by LiDCO rapidV3 monitoring system
Time frame: 10 minutes after entering the operating room; when 20% decrease in baseline MAP after both induction of anesthesia and intubation; when MAP rising to the highest point after administration of vasopressors