The dilation of perivascular spaces can be the result of various etiopathogenetic processes. White matter atrophy can cause enlargement of these perivascular spaces (PVS) but also obstruction of fluid drainage systems (interstitial fluid, ISF) and metabolites, as evidenced by some recent studies. Focal stagnation of liquids and deposition of toxic material induce tissue hypoxia and neuroglial dysfunction. Dilation of PVS can be associated with changes in white matter and microhemorrhages. We want to study these etiopathogenetic phenomena by implementing specific MRI methods.
Primary objective: the quantification of indirect magnetic resonance markers of altered waste drainage systems using validated scales in patients with white matter disease. Secondary objective: the evaluation of white matter alterations in relation to the known anatomical glymphatic pathways by analyzing both structural and diffusion data.
Study Type
OBSERVATIONAL
Enrollment
100
Patients will undergo a magnetic resonance imaging for clinical purposes to which additional sequences. Post gadolinium research sequences will be acquired only if intravenous gadolinium needs to be administered for clinical purposes.
Scientific Institute IRCCS Eugenio Medea
Bosisio Parini, Lecco, Italy
Extent of white matter lesions
T1 values of lesions
Time frame: once at recruitment
Number of perivascular spaces
count of perivascular spaces and total volume in disease population
Time frame: once at recruitment
Volume of parasagittal dural space
volume of parasagittal dural space in disease population
Time frame: once at recruitment
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