This is a study of a drug-drug interaction between XW003 and Metformin, Warfarin, Rosuvastatin or Digoxin
This is a single-center, open-label, fixed-sequence study designed to assess the effect of once-weekly subcutaneous injections of XW003 on the pharmacokinetics of metformin, warfarin, rosuvastatin or digoxin. Approximately 56 healthy subjects are to be enrolled into 2 parallel trial groups, with 28 subjects and 2 drugs evaluated in each of the trial group
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
57
Administered subcutaneously
Administered orally
Administered orally
West China Second University Hospital, Sichuan University
Chengdu, Sichuan, China
Pharmacokinetics of metformin: AUC0-inf
Time frame: up to 101 days
Pharmacokinetics of S-warfarin and R-warfarin: AUC0-inf
Time frame: up to 114 days
Pharmacokinetics of rosuvastatin: AUC0-inf
Time frame: up to 102 days
Pharmacokinetics of digoxin: AUC0-inf
Time frame: up to 112days
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Administered orally
Administered orally