A Study to Evaluate Tolerability, Safety and Immunogenicity of MVX01 Pneumococcal Vaccine

Inclusion Criteria: * Participant must be male or non-pregnant, non-lactating female ≥ 18 to ≤ 50 years of age for Cohorts 1 to 4 and ≥ 60 to ≤ 75 years of age for Cohort 5, at the time of signing the informed consent. * Body mass index within the range 18 to 32 kg/m2 (inclusive) for Cohorts 1-4. Body mass index within the range 18 to 35 kg/m2 (inclusive) for Cohort 5. * Participants who are free of clinically significant acute or chronic health conditions in the opinion of the Investigator. * Have provided written informed consent prior to screening procedures. * Participant's screening laboratory test results must be either within the normal range or deemed as not clinically significant by the Investigator. * Venous access considered adequate for collection of safety laboratory samples and immunogenicity samples. * Contraceptive use by males and females should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies. In addition, women of childbearing potential must agree to avoid heterosexual activity for a period of 14 days prior to the administration of study intervention. Exclusion Criteria: * Positive screening test suggesting a current infection due to human immunodeficiency virus, hepatitis C virus, or hepatitis B virus infection. * Symptoms of active respiratory illness at the time of the first dose of study intervention or close contact with a known SARS-CoV-2 positive patient within 10 days of first dose of study intervention. * Suspected or known alcohol and/or illicit drug abuse within the past 5 years. * Regular use of tobacco- or nicotine-containing products within 6 months prior to screening. * Electrocardiogram abnormalities outside of accepted ranges (with some exceptions) or results considered to be clinically significant. Participants with QT interval corrected for heart rate according to Fridericia's formula \> 450 msec (if male) or \> 460 msec (if female) will be excluded. * History of confirmed pneumococcal infection based on participant report of medical history during the previous 12 months. * Use of any investigational (non-registered) drug within 30 days or 5 half-lives of the investigational drug prior to receiving the first dose of study intervention. All investigational (non-registered) drugs used should be noted. * Use of chronic immunosuppressant agents or other immune-modifying drugs within 6 months prior to receiving the first dose of study intervention. Short-term use of corticosteroids (\< 14 days) for an acute illness are allowed but last dose should be ≥ 28 days prior to administration of the first dose of study intervention. The use of topical, inhaled, and nasal glucocorticoids is permitted. * Receipt of immunoglobulins and/or any blood products within the 3 months preceding Day 1 or planned administration of such products during the study and up Visit 6 (Day 57 \[± 4 days\]). * Is planning to become pregnant in the time period from Screening up to 30 days following the last dose of study intervention. * History of allergic disease, neurologic disease, or untoward reactions likely to be exacerbated by any component of the vaccine and/or known hypersensitivity to any component of the vaccine. * Any condition that in the opinion of the Investigator would pose a health risk to the participant if enrolled or could interfere with evaluation of the study intervention or interpretation of study results (including neurologic or psychiatric conditions deemed likely to impair the quality of safety reporting). * Known or suspected severe immunological dysfunction in the opinion of the Investigator. * History of administration of any vaccine within 30 days of prior to receiving the first dose of study intervention. Should a vaccine have been administered within the 30-day timeframe, inclusion into the study will be at the discretion of the Investigator. Vaccines may not be administered until after Visit 6 (Day 57 \[± 4 days\]). Participants should not intend to receive a licensed pneumococcal vaccine until after Visit 7 (Day 210 \[± 14 days\]). Participants will not be excluded based on previously having received a licensed pneumococcal vaccine as long as it was administered at least 30 days prior to receiving the first dose of study intervention. * Unwilling or unable to forego donation of sperm, egg, blood, plasma, or platelets from Screening through Visit 6 (Day 57 \[± 4 days\]). * In the opinion of the Investigator, any participant with a physical or laboratory finding or past medical history that might suggest a good quality of life for the participant is likely to be \< 24 months at the time of Screening examination. * Participants who, in the opinion of the Investigator, will not be able to comply with all the study procedures and visits as outlined in the protocol, including follow-up. * A staff member or family member of a staff member of the clinical research organization.