Anlotinib Combined With Penpulimab as Front-line Treatment in Advanced Non-small Cell Lung Cancer

Inclusion Criteria: * Age ≥18 years old (calculated on the date of signing the informed consent); * ECOG PS: 0-1; * Expected survival ≥3 months; * histopathologically confirmed non-small cell lung cancer with at least one measurable lesion (according to RECIST 1.1); * Patients who provided detectable specimens (tissue or cancerous pleural fluid) for genotype testing before enrollment, and whose EGFR and ALK gene test results were negative; Or patients with negative test results; Or patients with positive test results and who are resistant or intolerant after receiving relevant targeted drug therapy. * Have not been treated with a systematic regimen; * Patients voluntarily join the project and sign informed consent; * The function of vital organs is normal * Physicians can benefit from anrotinib hydrochloride combined immunotherapy based on current clinical practice assessment; * Patients voluntarily join the project and sign informed consent; * Require initiation of antirotinib hydrochloride combined immunotherapy within 28 days of informed consent; Exclusion Criteria: * Known allergy or metabolic disorder to any drug in the treatment regimen; * Those who refuse to take reliable contraceptive methods during pregnancy and lactation or in the appropriate age period; * Have any history of uncontrolled medical diseases (including uncontrolled diabetes, severe heart, lung, liver and kidney dysfunction, blood, endocrine system diseases, and other malignant tumors); * Have a history of psychotropic substance abuse, alcoholism or drug use; * Currently or about to participate in other anti-tumor drug clinical trials; * Have active, known, or suspected autoimmune diseases (including but not limited to: uveitis, enteritis, hepatitis, pituitaritis, nephritis, vasculitis, hyperthyroidism, hypothyroidism, and asthma requiring bronchodilator treatment, etc.). Patients with hypothyroidism who only need hormone replacement therapy, skin conditions that do not require systemic treatment (such as vitiligo, psoriasis, or alopecia) may be included; * During the 6 months prior to entering the study, the following conditions occurred: Myocardial infarction, severe/unstable angina pectoris, NYHA grade 2 or higher cardiac dysfunction, poorly controlled arrhythmias (including QTcF interphase \>450 ms in men, \> 470 ms in women, \>450 ms in women, \>450 ms in men, \> 470 ms in women, QTcF interval calculated by Fridericia formula), symptomatic congestive heart failure, cerebrovascular accident (including transient ischemic attack or symptomatic pulmonary embolism); * Patients receiving hematopoietic stem cells or organ transplants; * Other factors that may affect patient safety or compliance as determined by the investigator. Such as a serious illness (including mental illness) requiring co-treatment, serious laboratory abnormalities, or other family or social factors. Severe hepatic and renal insufficiency as judged by researchers.