This is a single center Phase I clinical trial of FT536 administered intraperitoneally (IP) 3 times a week for one week for the treatment of recurrent gynecologic cancers. A short course of outpatient lymphodepleting chemotherapy is given prior to the first dose of FT536 to promote adoptive transfer.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
3
FT536 is an allogeneic natural killer (NK)-cell immunotherapy produced from a clonal master humaninduced pluripotent stem cell (iPSC) line.
Fludarabine 25 mg/m2 IV given on day -5. Given consecutively with CY.
CY 300 mg/m2 IV given on day -4. Given consecutively with Fludarabine.
University of Minnesota Masonic Cancer Center
Minneapolis, Minnesota, United States
Progression free survival (PFS)
Time frame: 1 year
Progression free survival (PFS)
Time frame: 6 months
Overall survival (OS)
Time frame: 6 months
Overall survival (OS)
Time frame: 1 year
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