Acute Kidney Injury in Patients With Liver Cirrhosis

Sohag University180 enrolled

Overview

In our locality, limited studies have discussed AKI in patients with liver cirrhosis and its outcome, therefore we aim to highlight the incidence, patterns, risk factors, and outcomes of acute kidney injury in patients with liver cirrhosis at Sohag University Hospital.

Acute kidney injury (AKI) is a common condition in patients with cirrhosis. It occurs in up to 50% of hospitalized patients with cirrhosis and in 58% of such patients in the intensive care unit. AKI is one of the key predictors for short-term mortality in patients with liver cirrhosis with mortality rates as high as 90%. There is a remarkable increase in length of hospital stay with high financial burden on patients with AKI. In general, the three main causes of AKI are renal hypoperfusion (also referred to as prerenal AKI), which in most cases is due to hypovolemia; intrinsic, structural kidney injury; and postrenal injury due to urinary obstruction. A unique cause of AKI due to renal hypoperfusion in patients with cirrhosis is the hepatorenal syndrome (HRS), which is the result of renal vasoconstriction. Early identification and management of AKI may improve outcomes. In our locality, limited studies have discussed AKI in patients with liver cirrhosis and its outcome, therefore we aim to highlight the incidence, patterns, risk factors, and outcomes of acute kidney injury in patients with liver cirrhosis.

Study Type

OBSERVATIONAL

Enrollment

180

Conditions

Acute Kidney Injury in Patients With Liver Cirrhosis

Interventions

serum creatinineDIAGNOSTIC_TEST

to detect patients with Acute kidney injury

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Cirrhotic patients ( age more than 18 years old ) in Sohag University Hospital Exclusion Criteria: * patients with known preexisting chronic kidney disease * patients who had undergone renal transplantation * malignancy * pregnancy

Locations (1)

Sohag University Hospital

Sohag, Sohag Governorate, Egypt

Outcomes

Primary Outcomes

Incidence of acute kidney injury in cirrhotic patients in Sohag University Hospital

Number of new cases of acute kidney injury (which will be diagnosed by either increase in serum creatinine ≥0.3 mg/dl within 48 hours; or, a percentage increase in serum creatinine ≥50% within the prior seven days) occurring in cirrhotic patients in Sohag University Hospital.

Time frame: 1 year

Data from ClinicalTrials.gov

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