Following myocardial infarction, female individuals demonstrate a poorer prognosis, characterized by elevated rates of mortality and heart failure. A primary hypothesis suggests unfavorable cardiac remodeling in women. This remodeling, defined as alterations in cardiac size and shape post-infarction, necessitates repeated non-invasive imaging for study.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
1,650
non-invasive cardiac imaging (echocardiography and MRI)
University Hospital, Angers
Angers, France
RECRUITINGAsses left ventricular remodeling disparities between genders
The primary outcome measure will be the occurrence of left ventricular remodeling (defined as a change in ventricular volume of more than 10% during follow-up) measured with cardiac imaging (echocardiography and MRI)
Time frame: baseline; 3 months and 1 year after myocardial infarction onset
Evaluate the evolution of remodeling at Month 3
Changes in ventricular volumes between acute phase and 3 months measured with cardiac imaging (echocardiography and MRI)
Time frame: 3 months
Assess remodeling changes between inclusion and Month 12
Changes in ventricular volumes between acute phase and 1 year measured with cardiac imaging (echocardiography and MRI)
Time frame: 1 year
Assess the prevalence of comorbidities and their impact on the effect on the outcome: post-infarction cardiac remodeling with gender (cardiovascular risk factors, renal function, hepatic functionperipheral artery disease, way of life)
renal function: uremia and creatinine levels, combined with an assessment of the protein-to-creatinine ratio in urine samples, and a cyto-bacteriological examination of urine to detect hematuria; hepatic function: The Fibroscan® is a device that enables a non-invasive and efficient assessment of liver fibrosis and steatosis within minutes at the patient's bedside, providing an immediate result displayed on the device screen; peripheral artery disease: Doppler echocardiography of the supra-aortic trunks; way of life : dietetary, stress and physical activity scores common CV risk factors: prior history of hypertension, hypercholesterolaemia, tobacco use, diabetes
Time frame: 3 months and 1 year
Explore prognostic disparities between men and women.
Occurrence of complications and cardiovascular events (cardiovascular death, heart failure, stroke, or reinfarction)
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Time frame: yearly, up to 10 years
Evaluate lifestyle habits up to 10 years: outcome anxiety/depression
Anxiety/Depression (A.D) score: 2 scales from 0 to 21, the greatest the more prone to either anxiety or depression
Time frame: yearly, up to 10 years
Evaluate lifestyle habits up to 10 years: outcome diet score
Mediteranean diet score (MED): from 0 to 14, the greatest the more relevant for mediteranean diet
Time frame: yearly, up to 10 years
Evaluate lifestyle habits up to 10 years: outcome physical activity
physical activity: lipid research clinics (LRC); 2 scales from 1 to 5, the greatest the less active
Time frame: yearly, up to 10 years
Assess the risk of remodeling based on specific parameters in female subjects: presence of endometriosis
presence or absence of endometriosis
Time frame: baseline
Assess the risk of remodeling based on specific parameters in female subjects: presence of polycystic ovary
presence or absence of polycystic ovary
Time frame: baseline
Assess the risk of remodeling based on specific parameters in female subjects: presence of uterine fibroma
presence or absence of uterine fibroma
Time frame: baseline
Assess the risk of remodeling based on specific parameters in female subjects: presence of hormonal therapy
presence or absence of hormonal therapy
Time frame: baseline
Assess the risk of remodeling based on specific parameters in female subjects: date of first period
date of first period
Time frame: baseline
Assess the risk of remodeling based on specific parameters in female subjects: pregnancy
number of pregnancy
Time frame: baseline
Assess the risk of remodeling based on specific parameters in female subjects: children
number of children
Time frame: baseline
Assess the risk of remodeling based on specific parameters in female subjects: obstetrical event
absence or presence of obstetrical events (hypertension, diabete, microsomia and macrosomia)
Time frame: baseline
Assess the risk of remodeling based on specific parameters in female subjects: menopause
absence or presence of menopause
Time frame: baseline