Cellular, Molecular and Clinical Determinants of Bone Strength in in Vivo and Human Models of GH Excess.

Inclusion Criteria: * confirmed diagnosis of acromegaly * availability to carry out outpatient checks * ability to provide informed consent Exclusion Criteria: * Pregnancy * use of glucocorticoids (except those in use for replacement therapy) * alcohol abuse * exacerbation of chronic disease * serious comorbidities (renal or hepatic failure, heart attack, stroke) * terminally ill, prolonged immobilization (\>1 week) * clinically evident fracture within the previous six months * any other cause of secondary osteoporosis within the last five years * any prolonged treatment with drugs with documented influence on bone metabolism during the previous 12 months, including treatment with antiresorptive or anabolic compounds for osteoporosis.