Diphenhydramine in Catheter Related Bladder Discomfort

N/AEnrolling By InvitationNCT06345261

Cairo University104 enrolled

Overview

Diphenhydramine has H1-antihistamine action, it also possesses anti-muscarinic properties. Thus, diphenhydramine might be able to reduce the problem of catheter related bladder discomfort by inhibiting smooth muscle spasm of the urinary bladder via its anti-muscarinic action .

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

104

Conditions

Catheter Complications

Interventions

DiphenhydrAMINE 50 Mg/mL Injectable SolutionDRUG

injection of Diphenhydramine 50 Mg/mL

SalineDRUG

injection of saline

Eligibility

Sex: MALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: male patients aged more than18-80 years ASA I and II , upper ureteric stone removal under general anesthesia r Exclusion Criteria: overactive bladder cognitive impairment a neuropsychological disorder, bladder outflow obstruction urinary tract infection, , neurogenic bladder, operative time \> 6 h

Locations (1)

Cairo university

Cairo, Egypt

Outcomes

Primary Outcomes

incidence of catheter related bladder discomfort postoperative

* none, did not complain of any CRBD even upon asking. * mild, revealed only on questioning. * moderate, reported without questioning but not accompanied by any behavioral response. * severe, stated on their own and followed by behavioral responses such as a strong verbal response, flailing limbs, and even attempting to pull out the urinary catheter

Time frame: UP TO 6 HOURE

Secondary Outcomes

visual analog scale (VAS)

0 (no pain) to 10 (the worst imaginable pain)

Time frame: up to 6 hours

Data from ClinicalTrials.gov

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