The goal of this clinical trial is to verify the effectiveness and safety of the low load blood flow restriction training program. The intervention effect, tolerance and compliance of low load blood flow restriction training and progressive resistance training on lung cancer patients complicated with sarcopenia during chemotherapy will be compared, in order to provide new ideas for improving or reversing sarcopenia. The main questions it aims to answer are: Can low load blood flow restriction training improve sarcopenia in chemotherapy induced lung cancer patients? Which training method is more effective and tolerable between low load blood flow restriction training and progressive resistance training? Participants will be randomly divided into 3 groups: 1. Routine care group (Control group, CON): The researchers will provide participants with regular exercise and dietary guidance. 2. Low load blood flow restriction group (LL-BFRT): The researchers will provide participants with a low load blood flow restriction training program constructed by our research group. 3. Progressive resistance training group (PRE): The researchers will provide participants with progressive resistance training.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
104
Low load blood flow restriction training will be conducted on the subjects three times a week. Each training session includes upper and lower limb training, with 4 groups trained and repeated 30, 15, 15, and 15 times for each group. Train for a total of 12 weeks.The resistance strength will remain at 30% RM for weeks 1-12.
The subjects will undergo progressive resistance training three days a week, three groups per day, with each group repeating 10 times. Training includes upper and lower limbs. The resistance load increases over time, with a resistance load of 30% RM for weeks 1-4, 50% RM for weeks 5-8, and 70% RM for weeks 9-12.
The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
Grip strength
The grip strength of the participant's preferred hand
Time frame: Grip strength will be measured at 3, 6, 9, and 12 weeks after intervention
Appendicular Skeletal Muscle Index (ASMI)
Using a human body composition analyzer (ICOMEON-FI2001B) to measure the skeletal muscle mass (ASM) of the limbs, and calculating ASMI using a formula. ASMI=ASM/height\^2
Time frame: ASMI will be measured at 3, 6, 9, and 12 weeks after intervention
Step speed
Measure the walking speed of 6m
Time frame: Step speed will be measured at 3, 6, 9, and 12 weeks after intervention
Body mass index (BMI)
Measure height and weight using height measuring instruments and scales
Time frame: BMI will be measured at 3, 6, 9, and 12 weeks after intervention
Quality of life for lung cancer patients
Using the QLQ-LC 43 scale to measure the quality of life in lung cancer patients
Time frame: Quality of life for lung cancer patients will be measured at 3, 6, 9, and 12 weeks after intervention
Exercise compliance
This includes participation rate, interruption rate (number of missed training sessions), termination rate (termination of training before 12 weeks), and dose adjustment rate (adjustment of training load or frequency)
Time frame: Exercise compliance will be measured at12 weeks after intervention
Exercise safety
Record the frequency and time of adverse events caused by exercise, such as muscle pain, joint pain, dizziness, skin bruising, etc., and calculate the incidence rate of adverse events
Time frame: Exercise safety will be measured at12 weeks after intervention
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